A novel gene associated with small bowel bleeding in patients taking low-dose aspirin.
Aged
Aspirin
/ administration & dosage
Capsule Endoscopy
Cytochrome P450 Family 4
/ genetics
Female
Gastrointestinal Hemorrhage
/ chemically induced
Genome-Wide Association Study
Glutathione S-Transferase pi
/ genetics
Humans
Intestinal Diseases
/ chemically induced
Intestine, Small
/ pathology
Male
Pharmacogenomic Variants
/ genetics
Polymorphism, Single Nucleotide
/ genetics
Propensity Score
Risk Factors
CYP4F11
GSTP-1
Single nucleotide polymorphism
Small bowel bleeding
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
08
03
2021
revised:
30
04
2021
accepted:
30
04
2021
pubmed:
2
6
2021
medline:
2
2
2022
entrez:
1
6
2021
Statut:
ppublish
Résumé
We have previously revealed the clinical factors and genetic polymorphisms associated with gastrointestinal mucosal injury and bleeding, induced by low-dose aspirin (LDA). After performing genome-wide analysis of single nucleotide polymorphisms (SNPs) using the Drug Metabolizing Enzymes and Transporters (DMET) system among drug metabolism and transporter genes, certain SNPs were found to increase the risk for LDA-induced small bowel bleeding. The aim of this study was to identify the SNPs involved in LDA-induced small bowel bleeding. Subjects were patients taking LDA, with small bowel bleeding diagnosed using capsule endoscopy. We investigated the clinical characteristics and the previously identified SNPs, that were examined by the DNA direct sequence method. 56 patients with bleeding and 410 controls taking LDA were enrolled. The risk factors associated with small bowel bleeding included smoking, cerebrovascular diseases, chronic renal failure, non-steroidal anti-inflammatory drug (NSAID) or anticoagulants combination, and two SNPs (CYP4F11 20043G>A (D446N) rs1060463, GSTP1 313A>G rs1695). After propensity score matching, GSTP1 rs1695 was significantly associated with small bowel bleeding. The GSTP1 SNP may be a predictive marker for small bowel bleeding among patients taking LDA.
Identifiants
pubmed: 34059446
pii: S1590-8658(21)00243-7
doi: 10.1016/j.dld.2021.04.038
pii:
doi:
Substances chimiques
Cytochrome P450 Family 4
EC 1.14.14.1
CYP4F11 protein, human
EC 1.14.14.78
GSTP1 protein, human
EC 2.5.1.18
Glutathione S-Transferase pi
EC 2.5.1.18
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
841-845Informations de copyright
Copyright © 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.