Triple-hit high-grade B-cell lymphoma presenting with ovarian torsion.
gynaecological cancer
haematology (incl blood transfusion)
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
entrez:
1
6
2021
pubmed:
2
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
We report a case of a previously healthy woman in her early 70s who presented with 2 weeks of episodic abdominal pain and significant weight loss. Imaging of her abdomen revealed acute right ovarian torsion associated with bilateral ovarian enlargement and an indeterminant pelvic mass. An urgent laparoscopic bilateral oophorectomy was performed with pathological results consistent with triple-hit high-grade B-cell lymphoma. She was successfully treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab, intrathecal methotrexate and venetoclax with complete remission after three cycles. Ovarian lymphoma is a rare entity and its genetic features have not been well described. We performed a literature review, describe the current knowledge regarding ovarian lymphoma and its therapeutic implication in the genomic age.
Identifiants
pubmed: 34059546
pii: 14/5/e242423
doi: 10.1136/bcr-2021-242423
pmc: PMC8169459
pii:
doi:
Substances chimiques
Rituximab
4F4X42SYQ6
Vincristine
5J49Q6B70F
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Br J Obstet Gynaecol. 1988 Apr;95(4):386-90
pubmed: 3382612
Am J Case Rep. 2012;13:96-8
pubmed: 23569499
Cancer. 1974 Aug;34(2):397-407
pubmed: 4853080
Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):90-9
pubmed: 25696840
Pathol Res Pract. 2018 Apr;214(4):593-598
pubmed: 29519565
Blood. 2016 Feb 18;127(7):869-81
pubmed: 26702065
Biol Blood Marrow Transplant. 2018 Mar;24(3):514-520
pubmed: 29196080
Blood. 2013 Mar 21;121(12):2253-63
pubmed: 23335369
Hematology Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):1-9
pubmed: 33275682
Br J Haematol. 2014 Sep;166(6):891-901
pubmed: 24943107
Adv Anat Pathol. 2001 Jul;8(4):200-17
pubmed: 11444509
Am J Surg Pathol. 1993 Feb;17(2):154-70
pubmed: 8422111
Blood. 2016 May 19;127(20):2375-90
pubmed: 26980727
Lancet Haematol. 2018 Dec;5(12):e609-e617
pubmed: 30501868
Blood. 2020 Feb 20;135(8):523-533
pubmed: 31790142
J Clin Oncol. 2012 Oct 1;30(28):3452-9
pubmed: 22851565
Blood. 2016 May 5;127(18):2182-8
pubmed: 26834242
Br J Haematol. 2015 Aug;170(4):504-14
pubmed: 25907897
Ceska Gynekol. 2018 Winter;83(1):45-49
pubmed: 29510639
Med Oncol. 2011 Dec;28(4):1559-64
pubmed: 20509008
Gynecol Oncol. 1997 Mar;64(3):446-50
pubmed: 9062148