Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia.
Aged
COVID-19
/ diagnostic imaging
Female
Heparin, Low-Molecular-Weight
/ therapeutic use
Humans
Intubation, Intratracheal
/ statistics & numerical data
Kaplan-Meier Estimate
Male
Middle Aged
Respiration, Artificial
/ statistics & numerical data
Retrospective Studies
Risk Assessment
Rome
Severity of Illness Index
COVID-19 Drug Treatment
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 05 2021
31 05 2021
Historique:
received:
24
11
2020
accepted:
17
05
2021
entrez:
1
6
2021
pubmed:
2
6
2021
medline:
16
6
2021
Statut:
epublish
Résumé
Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical progression in patients with COVID-19 pneumonia. Patients admitted to a COVID-hospital in Rome with SARS-CoV-2 infection and mild/moderate pneumonia were retrospectively evaluated. The primary endpoint was the time from hospital admission to orotracheal intubation/death (OTI/death). A total of 449 patients were included: 39% female, median age 63 (IQR, 50-77) years. The estimated probability of OTI/death for patients receiving pLMWH was: 9.5% (95% CI 3.2-26.4) by day 20 in those not receiving pLMWH vs. 10.4% (6.7-15.9) in those exposed to pLMWH; p-value = 0.144. This risk associated with the use of pLMWH appeared to vary by PaO
Identifiants
pubmed: 34059708
doi: 10.1038/s41598-021-90713-6
pii: 10.1038/s41598-021-90713-6
pmc: PMC8167179
doi:
Substances chimiques
Heparin, Low-Molecular-Weight
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11334Subventions
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : rogetto COVID 2020 12371675
Investigateurs
Maria Alessandra Abbonizio
(MA)
Amina Abdeddaim
(A)
Elisabetta Agostini
(E)
Fabrizio Albarello
(F)
Gioia Amadei
(G)
Alessandra Amendola
(A)
Maria Assunta Antonica
(MA)
Mario Antonini
(M)
Tommaso Ascoli Bartoli
(TA)
Francesco Baldini
(F)
Raffaella Barbaro
(R)
Barbara Bartolini
(B)
Rita Bellagamba
(R)
Martina Benigni
(M)
Nazario Bevilacqua
(N)
Gianluigi Biava
(G)
Michele Bibas
(M)
Licia Bordi
(L)
Veronica Bordoni
(V)
Evangelo Boumis
(E)
Marta Branca
(M)
Rosanna Buonomo
(R)
Donatella Busso
(D)
Marta Camici
(M)
Flaminia Canichella
(F)
Maria Rosaria Capobianchi
(MR)
Alessandro Capone
(A)
Cinzia Caporale
(C)
Emanuela Caraffa
(E)
Ilaria Caravella
(I)
Fabrizio Carletti
(F)
Concetta Castilletti
(C)
Adriana Cataldo
(A)
Stefano Cerilli
(S)
Carlotta Cerva
(C)
Roberta Chiappini
(R)
Pierangelo Chinello
(P)
Maria Assunta Cianfarani
(MA)
Carmine Ciaralli
(C)
Claudia Cimaglia
(C)
Nicola Cinicola
(N)
Veronica Ciotti
(V)
Francesca Colavita
(F)
Angela Corpolongo
(A)
Massimo Cristofaro
(M)
Salvatore Curiale
(S)
Alessandra D'Abramo
(A)
Cristina Dantimi
(C)
Alessia De Angelis
(A)
Giada De Angelis
(G)
Maria Grazia De Palo
(MG)
Federico De Zottis
(F)
Virginia Di Bari
(V)
Rachele Di Lorenzo
(R)
Federica Di Stefano
(F)
Gianpiero D'Offizi
(G)
Francesca Evangelista
(F)
Francesca Faraglia
(F)
Anna Farina
(A)
Federica Ferraro
(F)
Lorena Fiorentini
(L)
Andrea Frustaci
(A)
Matteo Fusetti
(M)
Marisa Fusto
(M)
Vincenzo Galati
(V)
Roberta Gagliardini
(R)
Paola Gallì
(P)
Gabriele Garotto
(G)
Ilaria Gaviano
(I)
Saba Gebremeskel Tekle
(SG)
Maria Letizia Giancola
(ML)
Filippo Giansante
(F)
Emanuela Giombini
(E)
Guido Granata
(G)
Maria Cristina Greci
(MC)
Elisabetta Grilli
(E)
Susanna Grisetti
(S)
Marta Iaconi
(M)
Giuseppina Iannicelli
(G)
Carlo Inversi
(C)
Eleonora Lalle
(E)
Maria Elena Lamanna
(ME)
Simone Lanini
(S)
Daniele Lapa
(D)
Luciana Lepore
(L)
Raffaella Libertone
(R)
Raffaella Lionetti
(R)
Giuseppina Liuzzi
(G)
Laura Loiacono
(L)
Andrea Lucia
(A)
Franco Lufrani
(F)
Manuela Macchione
(M)
Gaetano Maffongelli
(G)
Alessandra Marani
(A)
Andrea Mariano
(A)
Maria Cristina Marini
(MC)
Micaela Maritti
(M)
Annelisa Mastrobattista
(A)
Ilaria Mastrorosa
(I)
Giulia Matusali
(G)
Valentina Mazzotta
(V)
Paola Mencarini
(P)
Silvia Meschi
(S)
Francesco Messina
(F)
Sibiana Micarelli
(S)
Giulia Mogavero
(G)
Annalisa Mondi
(A)
Marzia Montalbano
(M)
Chiara Montaldo
(C)
Silvia Mosti
(S)
Silvia Murachelli
(S)
Maria Musso
(M)
Michela Nardi
(M)
Assunta Navarra
(A)
Martina Nocioni
(M)
Pasquale Noto
(P)
Roberto Noto
(R)
Alessandra Oliva
(A)
Ilaria Onnis
(I)
Sandrine Ottou
(S)
Claudia Palazzolo
(C)
Emanuele Pallini
(E)
Fabrizio Palmieri
(F)
Giulio Palombi
(G)
Carlo Pareo
(C)
Virgilio Passeri
(V)
Federico Pelliccioni
(F)
Giovanna Penna
(G)
Antonella Petrecchia
(A)
Ada Petrone
(A)
Elisa Pianura
(E)
Carmela Pinnetti
(C)
Maria Pisciotta
(M)
Pierluca Piselli
(P)
Silvia Pittalis
(S)
Agostina Pontarelli
(A)
Costanza Proietti
(C)
Vincenzo Puro
(V)
Paolo Migliorisi Ramazzini
(PM)
Alessia Rianda
(A)
Gabriele Rinonapoli
(G)
Silvia Rosati
(S)
Dorotea Rubino
(D)
Martina Rueca
(M)
Alberto Ruggeri
(A)
Alessandra Sacchi
(A)
Alessandro Sampaolesi
(A)
Francesco Sanasi
(F)
Carmen Santagata
(C)
Alessandra Scarabello
(A)
Silvana Scarcia
(S)
Paola Scognamiglio
(P)
Laura Scorzolini
(L)
Giulia Stazi
(G)
Giacomo Strano
(G)
Chiara Taibi
(C)
Giorgia Taloni
(G)
Tetaj Nardi
(T)
Roberto Tonnarini
(R)
Simone Topino
(S)
Martina Tozzi
(M)
Francesco Vairo
(F)
Maria Beatrice Valli
(MB)
Laura Vincenzi
(L)
Ubaldo Visco-Comandini
(U)
Serena Vita
(S)
Pietro Vittozzi
(P)
Mauro Zaccarelli
(M)
Antonella Zanetti
(A)
Sara Zito
(S)
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