Novel daidzein molecules exhibited anti-prostate cancer activity through nuclear receptor ERβ modulation,

Animals Caspases / drug effects Cell Line, Tumor Cell Proliferation / drug effects Cell Survival Cyclin D1 / drug effects Dose-Response Relationship, Drug Estrogen Receptor beta / drug effects Female Genistein / pharmacology Humans Isoflavones / pharmacology Male Mice Mice, Inbred C57BL Prostatic Neoplasms / pathology Rats Rats, Sprague-Dawley Receptors, Estrogen / drug effects Tumor Burden / drug effects Xenograft Model Antitumor Assays
Deoxybenzoins anti-androgen anticancer caspase estrogen receptor receptor binding studies

Journal

Journal of chemotherapy (Florence, Italy)
ISSN: 1973-9478
Titre abrégé: J Chemother
Pays: England
ID NLM: 8907348

Informations de publication

Date de publication:
Dec 2021
Historique:
pubmed: 2 6 2021
medline: 4 2 2022
entrez: 1 6 2021
Statut: ppublish

Résumé

Eight novel ERβ selective daidzein analogues (NCE1-8) were synthesized and their anti-cancer activity was evaluated by

Identifiants

DOI: 10.1080/1120009X.2021.1924935 PMID: 34060437
pubmed: 34060437
doi: 10.1080/1120009X.2021.1924935
doi:

Substances chimiques

Estrogen Receptor beta 0
Isoflavones 0
Receptors, Estrogen 0
Cyclin D1 136601-57-5
daidzein 6287WC5J2L
Genistein DH2M523P0H
Caspases EC 3.4.22.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

582-594

Auteurs

R Ranjithkumar (R)

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

K Saravanan (K)

Drug Discovery Lab, Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.

B Balaji (B)

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

S Hima (S)

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.

S Sreeja (S)

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.

S R Timane (SR)

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

M Ram Pravin Kumar (M)

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

S Kabilan (S)

Drug Discovery Lab, Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.

M Ramanathan (M)

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Novel daidzein molecules exhibited...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Novel daidzein molecules exhibited...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Novel daidzein molecules exhibited...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Novel daidzein molecules exhibited...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Novel daidzein molecules exhibited...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Cycline D1 › Novel daidzein molecules exhibited...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Novel daidzein molecules exhibited...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur bêta des oestrogènes › Novel daidzein molecules exhibited...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Isoflavones › Génistéine › Novel daidzein molecules exhibited...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel daidzein molecules exhibited...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Isoflavones › Novel daidzein molecules exhibited...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Novel daidzein molecules exhibited...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Novel daidzein molecules exhibited...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Novel daidzein molecules exhibited...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Novel daidzein molecules exhibited...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Novel daidzein molecules exhibited...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Novel daidzein molecules exhibited...
questionsmedicales.fr › Techniques d'investigation › Charge tumorale › Novel daidzein molecules exhibited...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Novel daidzein molecules exhibited...