Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis.
Aminopyridines
/ chemical synthesis
Animals
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Movement
/ drug effects
Female
Humans
Intracellular Signaling Peptides and Proteins
/ metabolism
Male
Mice, Inbred BALB C
Molecular Structure
Neoplasm Metastasis
/ drug therapy
Neoplasms
/ drug therapy
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
pubmed:
2
6
2021
medline:
26
8
2021
entrez:
1
6
2021
Statut:
ppublish
Résumé
The gain of cell motility is an essential prerequisite for cancer metastasis. The ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1) has been demonstrated to regulate hypoxia-driven tumor cell migration. However, there is still a lack of methods for discovering inhibitors targeting the WSB1 axis. Here, we employed phenotypic screening models and identified compound
Identifiants
pubmed: 34060833
doi: 10.1021/acs.jmedchem.1c00586
doi:
Substances chimiques
Aminopyridines
0
Antineoplastic Agents
0
Intracellular Signaling Peptides and Proteins
0
Wsb1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM