Pore mutation N617D in the skeletal muscle DHPR blocks Ca

Animals Calcium / metabolism Calcium Channels, L-Type / genetics Calcium Signaling Cells, Cultured Excitation Contraction Coupling Mice, Transgenic Molecular Dynamics Simulation Muscle, Skeletal / metabolism Permeability Point Mutation Protein Binding Protein Conformation Structure-Activity Relationship
ca2+ permeation ca2+ selectivity molecular biophysics mouse nc dhpr non-conducting dhpr pore binding affinity skeletal muscle excitation-contraction coupling structural biology voltage-gated ca2+ channel

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
01 06 2021
Historique:
received: 24 09 2020
accepted: 28 05 2021
pubmed: 2 6 2021
medline: 21 10 2021
entrez: 1 6 2021
Statut: epublish

Résumé

Skeletal muscle excitation-contraction (EC) coupling roots in Ca

Identifiants

DOI: 10.7554/eLife.63435 PMID: 34061024 PMC: PMC8184209
pubmed: 34061024
doi: 10.7554/eLife.63435
pii: 63435
pmc: PMC8184209
doi:
pii:

Substances chimiques

CACNA1S protein, mouse 0
Calcium Channels, L-Type 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2021, Dayal et al.

Déclaration de conflit d'intérêts

AD, MF, KL, MG No competing interests declared

Références

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Auteurs

Anamika Dayal (A)

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
ORCID: 0000-0001-8075-8812

Monica L Fernández-Quintero (ML)

Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
ORCID: 0000-0002-6811-6283

Klaus R Liedl (KR)

Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
ORCID: 0000-0002-0985-2299

Manfred Grabner (M)

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
ORCID: 0000-0002-5196-4024

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Cellules › Cellules cultivées › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Couplage excitation-contraction › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Phénomènes chimiques › Perméabilité › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation ponctuelle › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Pore mutation N617D in the skeletal muscle...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Pore mutation N617D in the skeletal muscle...