Transient Mitochondria Dysfunction Confers Fungal Cross-Resistance against Phagocytic Killing and Fluconazole.
Antifungal Agents
/ pharmacology
Candida glabrata
/ drug effects
Candidiasis
/ microbiology
Drug Resistance, Fungal
/ genetics
Fluconazole
/ pharmacology
Gene Expression Regulation, Fungal
Humans
Macrophages
/ microbiology
Microbial Sensitivity Tests
Mitochondria
/ metabolism
Phagocytes
Phagocytosis
Virulence
/ genetics
antivirulence
cross-resistance
fungal infection
petite
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
29 06 2021
29 06 2021
Historique:
pubmed:
2
6
2021
medline:
19
11
2021
entrez:
1
6
2021
Statut:
ppublish
Résumé
Loss or inactivation of antivirulence genes is an adaptive strategy in pathogen evolution. Candida glabrata is an important opportunistic pathogen related to baker's yeast, with the ability to both quickly increase its intrinsic high level of azole resistance and persist within phagocytes. During C. glabrata's evolution as a pathogen, the mitochondrial DNA polymerase CgMip1 has been under positive selection. We show that
Identifiants
pubmed: 34061590
doi: 10.1128/mBio.01128-21
pmc: PMC8262853
doi:
Substances chimiques
Antifungal Agents
0
Fluconazole
8VZV102JFY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0112821Références
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