Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain.

Amino Acid Substitution Animals Brain / cytology Central Nervous System Diseases / virology Chlorocebus aethiops Female HEK293 Cells Humans Induced Pluripotent Stem Cells / pathology Male Measles / virology Measles virus / genetics Metagenomics Mice Neurons / virology Organoids / cytology Vero Cells Viral Fusion Proteins / chemistry
central nervous system infection host-pathogen interaction viral evolution viral fusion

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
29 06 2021
Historique:
pubmed: 2 6 2021
medline: 12 11 2021
entrez: 1 6 2021
Statut: ppublish

Résumé

Measles virus (MeV) bearing a single amino acid change in the fusion protein (F)-L454W-was isolated from two patients who died of MeV central nervous system (CNS) infection. This mutation in F confers an advantage over wild-type virus in the CNS, contributing to disease in these patients. Using murine

Identifiants

DOI: 10.1128/mBio.00799-21 PMID: 34061592 PMC: PMC8263006
pubmed: 34061592
doi: 10.1128/mBio.00799-21
pmc: PMC8263006
doi:

Substances chimiques

Viral Fusion Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0079921

Subventions

Organisme : NIAID NIH HHS
ID : R56 AI146980
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105699
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121349
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091263
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States

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Auteurs

Cyrille Mathieu (C)

Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
CIRI, Centre International de Recherche en Infectiologie, Team Immuno-Biology of Viral Infections, University of Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.

Francesca T Bovier (FT)

Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Experimental Medicine, University of Study of Campania "Luigi Vanvitelli", Naples, Italy.

Marion Ferren (M)

Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
CIRI, Centre International de Recherche en Infectiologie, Team Immuno-Biology of Viral Infections, University of Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.

Nicole A P Lieberman (NAP)

Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA.

Camilla Predella (C)

Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Alexandre Lalande (A)

CIRI, Centre International de Recherche en Infectiologie, Team Immuno-Biology of Viral Infections, University of Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.

Vikas Peddu (V)

Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA.

Michelle J Lin (MJ)

Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA.

Amin Addetia (A)

Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA.

Achchhe Patel (A)

Stem Cell Core Facility, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Victor Outlaw (V)

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Barbara Corneo (B)

Stem Cell Core Facility, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

N Valerio Dorrello (NV)

Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Thomas Briese (T)

Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.

Diana Hardie (D)

Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa.

Branka Horvat (B)

CIRI, Centre International de Recherche en Infectiologie, Team Immuno-Biology of Viral Infections, University of Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.

Anne Moscona (A)

Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Microbiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Physiology and Cellular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Alexander L Greninger (AL)

Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA.

Matteo Porotto (M)

Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Department of Experimental Medicine, University of Study of Campania "Luigi Vanvitelli", Naples, Italy.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Substitution d'acide aminé › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Eucaryotes › Animaux › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Mononegavirales › Infections à Paramyxoviridae › Infections à virus morbilleux › Rougeole › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Morbillivirus › Virus de la rougeole › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Métagénomique › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Cellules › Neurones › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Tissus › Organoïdes › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Molecular Features of the Measles Virus Viral...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Molecular Features of the Measles Virus Viral...