Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson's Disease Synucleinopathy.
BLAST
Parkinson’s disease
antibodies
antigen
cross-reactivity
food
gut-brain axis
sequence homology
synucleinopathy
α-synuclein
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 05 2021
05 05 2021
Historique:
received:
29
03
2021
revised:
24
04
2021
accepted:
03
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
25
2
2023
Statut:
epublish
Résumé
Parkinson's disease is characterized by non-motor/motor dysfunction midbrain neuronal death and α-synuclein deposits. The accepted hypothesis is that unknown environmental factors induce α-synuclein accumulation in the brain via the enteric nervous system. Monoclonal antibodies made against recombinant α-synuclein protein or α-synuclein epitope 118-123 were applied to the antigens of 180 frequently consumed food products. The specificity of those antibody-antigen reactions was confirmed by serial dilution and inhibition studies. The Basic Local Alignment Search Tool sequence matching program was used for sequence homologies. While the antibody made against recombinant α-synuclein reacted significantly with 86/180 specific food antigens, the antibody made against α-synuclein epitope 118-123 reacted with only 32/180 tested food antigens. The food proteins with the greatest number of peptides that matched with α-synuclein were yeast, soybean, latex hevein, wheat germ agglutinin, potato, peanut, bean agglutinin, pea lectin, shrimp, bromelain, and lentil lectin.
Identifiants
pubmed: 34063062
pii: cells10051111
doi: 10.3390/cells10051111
pmc: PMC8147930
pii:
doi:
Substances chimiques
Allergens
0
Dietary Proteins
0
Epitopes
0
alpha-Synuclein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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