The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease.
Addison’s disease
Cushing’s syndrome
adrenal cortex
adrenocortical carcinoma
proliferation
sex hormones
sexual dimorphism
stem cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 May 2021
05 May 2021
Historique:
received:
22
03
2021
revised:
26
04
2021
accepted:
28
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Many adrenocortical diseases are more prevalent in women than in men, but the reasons underlying this sex bias are still unknown. Recent studies involving gonadectomy and sex hormone replacement experiments in mice have shed some light onto the molecular basis of sexual dimorphism in the adrenal cortex. Indeed, it has been shown that gonadal hormones influence many aspects of adrenal physiology, ranging from stem cell-dependent tissue turnover to steroidogenesis and X-zone dynamics. This article reviews current knowledge on adrenal cortex sexual dimorphism and the potential mechanisms underlying sex hormone influence of adrenal homeostasis. Both topics are expected to contribute to personalized and novel therapeutic approaches in the future.
Identifiants
pubmed: 34063067
pii: ijms22094889
doi: 10.3390/ijms22094889
pmc: PMC8124132
pii:
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Worldwide Cancer Research
ID : 18-0437
Pays : United Kingdom
Organisme : Agence Nationale de la Recherche
ID : ANR-11-LABX-0028-01, ANR-18-CE14-0012
Organisme : Fondation pour la Recherche Médicale
ID : FRM SPF201809007141
Organisme : La Ligue Contre le Cancer
ID : Equipe Labelisée
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