Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats.
Animals
Dietary Supplements
Ecdysterone
/ metabolism
Fructosamine
/ blood
Gene Expression Profiling
Gene Expression Regulation
/ drug effects
Genotype
Lipid Metabolism
/ drug effects
Lipids
/ blood
Liver
/ drug effects
Male
Obesity
/ metabolism
Organ Size
/ drug effects
Rats, Zucker
Reproducibility of Results
20-hydroxyecdysone
cholesterol
ecdysterone
lipid metabolism
liver
obese Zucker rat
obesity
transcriptome
triglyceride
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 May 2021
15 May 2021
Historique:
received:
15
03
2021
revised:
11
05
2021
accepted:
13
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
2
7
2021
Statut:
epublish
Résumé
Conflicting reports exist with regard to the effect of ecdysterone, the predominating representative of steroid hormones in insects and plants, on hepatic and plasma lipid concentrations in different rodent models of obesity, fatty liver, and diabetes, indicating that the effect is dependent on the rodent model used. Here, the hypothesis was tested for the first time that ecdysterone causes lipid-lowering effects in genetically obese Zucker rats. To test this hypothesis, two groups of male obese Zucker rats (
Identifiants
pubmed: 34063487
pii: ijms22105241
doi: 10.3390/ijms22105241
pmc: PMC8156757
pii:
doi:
Substances chimiques
Lipids
0
Fructosamine
4429-04-3
Ecdysterone
5289-74-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutscher Akademischer Austauschdienst
ID : 57243780
Références
Curr Biol. 2019 Dec 2;29(23):R1252-R1268
pubmed: 31794762
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Anal Biochem. 1978 Oct 1;90(1):420-6
pubmed: 727482
BMC Complement Med Ther. 2020 May 6;20(1):140
pubmed: 32375750
Mol Nutr Food Res. 2014 Sep;58(9):1861-72
pubmed: 24974955
Phytochemistry. 2001 Jun;57(3):325-39
pubmed: 11393511
Int J Obes. 1982;6(6):557-66
pubmed: 6761289
Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E433-9
pubmed: 19126784
Nutrients. 2020 Apr 02;12(4):
pubmed: 32252339
Farmakol Toksikol. 1976 Nov-Dec;39(6):690-3
pubmed: 1030669
BMC Genomics. 2017 Mar 23;18(1):253
pubmed: 28335726
Eur J Pharmacol. 2013 Jan 5;698(1-3):489-98
pubmed: 23110815
J Agric Food Chem. 2008 May 28;56(10):3532-7
pubmed: 18444661
J Dairy Sci. 2017 Aug;100(8):6689-6706
pubmed: 28624282
Gen Comp Endocrinol. 1978 Aug;35(4):436-44
pubmed: 720815
Growth. 1983 Autumn;47(3):282-91
pubmed: 6196256
Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
pubmed: 12184808
PLoS One. 2017 Mar 2;12(3):e0173028
pubmed: 28253314
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
pubmed: 11752295
Nutr Metab (Lond). 2013 Jul 10;10:48
pubmed: 23842456
Physiol Behav. 2014 Apr 10;128:226-31
pubmed: 24534167
Mol Nutr Food Res. 2019 Apr;63(8):e1801305
pubmed: 30688013
Recent Prog Horm Res. 1980;36:401-49
pubmed: 6251519
J Nutr. 1994 Oct;124(10):1917-26
pubmed: 7931700
Curr Opin Clin Nutr Metab Care. 2004 Jul;7(4):443-50
pubmed: 15192448
J Dairy Sci. 2019 Jan;102(1):365-376
pubmed: 30487053
Obesity (Silver Spring). 2012 Feb;20(2):270-7
pubmed: 21869758
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Cell Mol Life Sci. 2001 Jul;58(8):1121-32
pubmed: 11529504
J Anim Sci. 2012 May;90(5):1532-40
pubmed: 22573839
J Nutr. 2019 Apr 1;149(4):566-577
pubmed: 30726942