Does Cancer Biology Rely on Parrondo's Principles?
Parrondo’s paradox
cancer
dormancy
metastasis
therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 May 2021
03 May 2021
Historique:
received:
09
04
2021
revised:
29
04
2021
accepted:
29
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Many aspects of cancer biology remain puzzling, including the proliferative and survival success of malignant cells in spite of their high genetic and epigenetic instability as well as their ability to express migrating phenotypes and/or enter dormancy despite possible fitness loss. Understanding the potential adaptive value of these phenotypic traits is confounded by the fact that, when considered separately, they seem to be rather detrimental at the cell level, at least in the short term. Here, we argue that cancer's biology and success could frequently be governed by processes underlying Parrondo's paradox, whereby combinations of intrinsically losing strategies may result in winning outcomes. Oncogenic selection would favor Parrondo's dynamics because, given the environmental adversity in which malignant cells emerge and evolve, alternating between various less optimal strategies would represent the sole viable option to counteract the changing and deleterious environments cells are exposed to during tumorigenesis. We suggest that malignant processes could be viewed through this lens, and we discuss how Parrondo's principles are also important when designing therapies against cancer.
Identifiants
pubmed: 34063648
pii: cancers13092197
doi: 10.3390/cancers13092197
pmc: PMC8125342
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : MAVA Foundation
ID : NA
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE35-0009
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