Association between Body Mass Index and Survival Outcome in Metastatic Cancer Patients Treated by Immunotherapy: Analysis of a French Retrospective Cohort.

advanced cancer body mass index immune-related adverse events immunotherapy survival toxicity

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
03 May 2021
Historique:
received: 12 03 2021
revised: 29 04 2021
accepted: 30 04 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

The response to immunotherapy has been little investigated in overweight and obese cancer patients. We evaluated the relationships between BMI, toxicity, and survival in patients treated by immunotherapy for metastatic cancer. We included metastatic cancer patients treated by immunotherapy between January 2017 and June 2020 at the Centre Léon Bérard. In total, 272 patients were included: 64% men and 36% women, with a median age of 61.4 years. BMI ≥ 25 in 34.2% and 50% had non-small cell lung cancer (

Identifiants

pubmed: 34063692
pii: cancers13092200
doi: 10.3390/cancers13092200
pmc: PMC8124396
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Laetitia Collet (L)

Department of Medical Oncology, Centre Léon Bérard, 69008 Lyon, France.

Lidia Delrieu (L)

Department of Prevention Cancer Environment, Léon Bérard Cancer Centre, 69008 Lyon, France.
Residual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, Institut Curie, Paris University, 75005 Paris, France.

Amine Bouhamama (A)

Radiology Department, Centre Léon Bérard, 69008 Lyon, France.

Hugo Crochet (H)

Data and Artificial Intelligence Team, Centre Léon Bérard, 69008 Lyon, France.

Aurélie Swalduz (A)

Department of Medical Oncology, Centre Léon Bérard, 69008 Lyon, France.

Alexandre Nerot (A)

Radiology Department, Centre Léon Bérard, 69008 Lyon, France.

Timothée Marchal (T)

Department of Supportive Care, Institut Curie, 75005 Paris, France.

Sylvie Chabaud (S)

Department of Clinical Research and Innovation, Léon Bérard Cancer Centre, 69008 Lyon, France.

Pierre Etienne Heudel (PE)

Department of Medical Oncology, Centre Léon Bérard, 69008 Lyon, France.

Classifications MeSH