Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma.

Merkel cell carcinoma Merkel cell polyomavirus immune checkpoint inhibitors immunotherapy microsatellite instability mismatch repair deficiency

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
21 May 2021
Historique:
received: 10 04 2021
revised: 14 05 2021
accepted: 16 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

We aimed to assess for the first time the mismatch repair (MMR) protein expression in Merkel cell carcinoma (MCC). Immunohistochemistry was performed for MLH1, MSH2, MSH6, and PMS2 on patients' tumor tissue (

Identifiants

pubmed: 34063983
pii: cancers13112524
doi: 10.3390/cancers13112524
pmc: PMC8196722
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : FoRUM research grant of the Ruhr-University Bochum
ID : F855N2-2015
Organisme : National Reference Center for Papilloma- and Polyomaviruses
ID : 1369-401

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Auteurs

Thilo Gambichler (T)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Nessr Abu Rached (N)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Andrea Tannapfel (A)

Institute of Pathology, Ruhr-University Bochum, 44789 Bochum, Germany.

Jürgen C Becker (JC)

Translational Skin Cancer Research, German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Department of Dermatology, University Duisburg-Essen, 45147 Essen, Germany.
Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany.

Markus Vogt (M)

Institute of Pathology, Ruhr-University Bochum, 44789 Bochum, Germany.

Marina Skrygan (M)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Ulrike Wieland (U)

National Reference Center for Papilloma- and Polyomaviruses, Institute of Virology, University of Cologne, 50935 Cologne, Germany.

Steffi Silling (S)

National Reference Center for Papilloma- and Polyomaviruses, Institute of Virology, University of Cologne, 50935 Cologne, Germany.

Laura Susok (L)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Markus Stücker (M)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Thomas Meyer (T)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Eggert Stockfleth (E)

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Klaus Junker (K)

Department of Pathology, Klinikum Bremen-Mitte, 28205 Bremen, Germany.

Heiko U Käfferlein (HU)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurances (IPA), Ruhr-University Bochum, 44789 Bochum, Germany.

Thomas Brüning (T)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurances (IPA), Ruhr-University Bochum, 44789 Bochum, Germany.

Kerstin Lang (K)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurances (IPA), Ruhr-University Bochum, 44789 Bochum, Germany.

Classifications MeSH