Structural Perspectives on the Mechanism of Soluble Guanylate Cyclase Activation.
cryo–electron microscopy
enzyme structure
nitric oxide
soluble guanylate cyclase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
03
05
2021
revised:
17
05
2021
accepted:
18
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
17
6
2021
Statut:
epublish
Résumé
The enzyme soluble guanylate cyclase (sGC) is the prototypical nitric oxide (NO) receptor in humans and other higher eukaryotes and is responsible for transducing the initial NO signal to the secondary messenger cyclic guanosine monophosphate (cGMP). Generation of cGMP in turn leads to diverse physiological effects in the cardiopulmonary, vascular, and neurological systems. Given these important downstream effects, sGC has been biochemically characterized in great detail in the four decades since its discovery. Structures of full-length sGC, however, have proven elusive until very recently. In 2019, advances in single particle cryo-electron microscopy (cryo-EM) enabled visualization of full-length sGC for the first time. This review will summarize insights revealed by the structures of sGC in the unactivated and activated states and discuss their implications in the mechanism of sGC activation.
Identifiants
pubmed: 34064029
pii: ijms22115439
doi: 10.3390/ijms22115439
pmc: PMC8196705
pii:
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Soluble Guanylyl Cyclase
EC 4.6.1.2
Cyclic GMP
H2D2X058MU
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM127854
Pays : United States
Organisme : NIH HHS
ID : GM127854
Pays : United States
Références
Nitric Oxide. 2009 Sep;21(2):92-103
pubmed: 19602444
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4156-64
pubmed: 25253889
BMC Struct Biol. 2008 Oct 07;8:42
pubmed: 18842118
Cell. 1991 Dec 20;67(6):1157-67
pubmed: 1760843
Mol Pharmacol. 2001 Feb;59(2):220-4
pubmed: 11160856
Bioessays. 2016 Sep;38(9):903-16
pubmed: 27492088
PLoS One. 2010 Jul 15;5(7):e11617
pubmed: 20657650
Science. 2014 Mar 28;343(6178):1443-4
pubmed: 24675944
Protein Sci. 2013 Oct;22(10):1439-44
pubmed: 23934793
Trends Biochem Sci. 2013 Nov;38(11):566-75
pubmed: 24113192
Methods Enzymol. 1996;268:281-93
pubmed: 8782594
Nat Chem Biol. 2017 Dec;13(12):1216-1221
pubmed: 28967923
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21602-7
pubmed: 20007374
Nature. 1997 Mar 20;386(6622):247-53
pubmed: 9069282
J Biol Chem. 1998 Jun 26;273(26):16332-8
pubmed: 9632695
Blood. 1994 Dec 15;84(12):4226-33
pubmed: 7527671
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15720-5
pubmed: 18840690
ACS Med Chem Lett. 2016 Feb 24;7(5):465-9
pubmed: 27190594
Nature. 2019 Oct;574(7777):206-210
pubmed: 31514202
Neuroscientist. 2010 Aug;16(4):435-52
pubmed: 20817920
BMC Struct Biol. 2010 Jan 27;10:2
pubmed: 20105301
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9
pubmed: 15326296
J Biol Chem. 2008 Jul 25;283(30):20968-77
pubmed: 18515359
Structure. 2014 Apr 8;22(4):602-11
pubmed: 24560804
J Biol Chem. 2015 Jun 19;290(25):15570-15580
pubmed: 25907555
Biochemistry. 2013 Mar 5;52(9):1568-82
pubmed: 23363317
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3203-7
pubmed: 20623
ACS Chem Biol. 2016 Aug 19;11(8):2337-46
pubmed: 27328180
Biochemistry. 1994 May 10;33(18):5636-40
pubmed: 7910035
Nitric Oxide. 2018 May 31;78:72-80
pubmed: 29859918
Biochem J. 1998 Oct 1;335 ( Pt 1):51-7
pubmed: 9742212
BMC Genomics. 2003 Feb 03;4(1):5
pubmed: 12590654
Chem Rev. 2017 Jun 28;117(12):7615-7672
pubmed: 28558231
Nat Methods. 2021 Feb;18(2):176-185
pubmed: 33542510
Biochemistry. 1998 Mar 31;37(13):4502-9
pubmed: 9521770
J Biol Chem. 2003 Apr 4;278(14):12590-7
pubmed: 12560334
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14753-8
pubmed: 10611285
Chembiochem. 2004 Feb 6;5(2):170-6
pubmed: 14760737
Science. 1997 Dec 12;278(5345):1907-16
pubmed: 9417641
Curr Med Chem. 2016;23(24):2770-2788
pubmed: 27776476
PLoS One. 2013;8(3):e57644
pubmed: 23505436
PLoS One. 2011;6(11):e26976
pubmed: 22096512
Biochemistry. 2007 Mar 27;46(12):3614-23
pubmed: 17319691
Science. 2004 Nov 26;306(5701):1550-3
pubmed: 15472039
J Pharmacol Exp Ther. 2018 Jun;365(3):664-675
pubmed: 29643251
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2960-5
pubmed: 24516165
Nature. 2001 Mar 8;410(6825):212-5
pubmed: 11242081
Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L179-84
pubmed: 16143586
Nitric Oxide. 2018 Jul 1;77:65-74
pubmed: 29704567
Biochemistry. 2000 Apr 11;39(14):4191-8
pubmed: 10747811
Compr Physiol. 2015 Apr;5(2):808-23
pubmed: 25880514
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13414-9
pubmed: 9391039
Drugs. 2013 Nov;73(17):1967-75
pubmed: 24218053
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6777-82
pubmed: 23572573
Nucleic Acids Res. 2021 Jan 8;49(D1):D412-D419
pubmed: 33125078
Biochemistry. 2005 Mar 15;44(10):4083-90
pubmed: 15751985
FEBS Lett. 1981 Sep 14;132(1):71-4
pubmed: 6117479
EMBO J. 1996 Dec 16;15(24):6863-8
pubmed: 9003762
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2592-6
pubmed: 7908439
Biochemistry. 2009 Aug 11;48(31):7519-24
pubmed: 19527054
Biochemistry. 2014 Apr 8;53(13):2153-65
pubmed: 24669844
Structure. 2009 Oct 14;17(10):1282-94
pubmed: 19836329
Biochemistry. 2004 Aug 10;43(31):10203-11
pubmed: 15287748
Curr Opin Nephrol Hypertens. 2014 Mar;23(2):135-42
pubmed: 24419369
Circulation. 2011 May 24;123(20):2263-73
pubmed: 21606405
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13064-9
pubmed: 16131543
EMBO J. 2004 Nov 10;23(22):4443-50
pubmed: 15510222
Elife. 2019 Sep 30;8:
pubmed: 31566566
Biochemistry. 1997 Dec 16;36(50):15959-64
pubmed: 9398330
Science. 1999 Jul 30;285(5428):756-60
pubmed: 10427002
Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62
pubmed: 27071111
J Biol Chem. 2008 Jan 11;283(2):1167-78
pubmed: 18006497
ACS Chem Biol. 2018 Jun 15;13(6):1631-1639
pubmed: 29757599