Neuroprotective Strategies in Aneurysmal Subarachnoid Hemorrhage (aSAH).
inflammation
metabolism
neuroprotection
subarachnoid hemorrhage (SAH)
therapy
thromboinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
17
03
2021
revised:
30
04
2021
accepted:
18
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
17
6
2021
Statut:
epublish
Résumé
Aneurysmal subarachnoid hemorrhage (aSAH) remains a disease with high mortality and morbidity. Since treating vasospasm has not inevitably led to an improvement in outcome, the actual emphasis is on finding neuroprotective therapies in the early phase following aSAH to prevent secondary brain injury in the later phase of disease. Within the early phase, neuroinflammation, thromboinflammation, disturbances in brain metabolism and early neuroprotective therapies directed against delayed cerebral ischemia (DCI) came into focus. Herein, the role of neuroinflammation, thromboinflammation and metabolism in aSAH is depicted. Potential neuroprotective strategies regarding neuroinflammation target microglia activation, metalloproteases, autophagy and the pathway via Toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1), NF-κB and finally the release of cytokines like TNFα or IL-1. Following the link to thromboinflammation, potential neuroprotective therapies try to target microthrombus formation, platelets and platelet receptors as well as clot clearance and immune cell infiltration. Potential neuroprotective strategies regarding metabolism try to re-balance the mismatch of energy need and supply following aSAH, for example, in restoring fuel to the TCA cycle or bypassing distinct energy pathways. Overall, this review addresses current neuroprotective strategies in aSAH, hopefully leading to future translational therapy options to prevent secondary brain injury.
Identifiants
pubmed: 34064048
pii: ijms22115442
doi: 10.3390/ijms22115442
pmc: PMC8196706
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Julius-Maximilians-Universität Würzburg
ID : Open Access Publishing Fund
Références
Stroke. 2010 Oct;41(10):2391-5
pubmed: 20798370
Nat Neurosci. 2018 Oct;21(10):1380-1391
pubmed: 30224810
Cell Death Dis. 2016 Mar 31;7:e2160
pubmed: 27031957
Nat Commun. 2020 Jun 22;11(1):3159
pubmed: 32572022
Transl Neurosci. 2019 Apr 23;10:104-111
pubmed: 31098320
Neurosurgery. 2006 Oct;59(4):781-7; discussion 787-8
pubmed: 16915120
Aging (Albany NY). 2020 Nov 30;13(1):694-713
pubmed: 33253120
J Neuroinflammation. 2012 Feb 08;9:28
pubmed: 22316109
Nat Rev Neurol. 2014 Jan;10(1):44-58
pubmed: 24323051
Clin Sci (Lond). 2017 Aug 10;131(17):2257-2274
pubmed: 28798076
J Neuroinflammation. 2019 Dec 2;16(1):247
pubmed: 31791369
Mol Neurobiol. 2019 Feb;56(2):976-985
pubmed: 29855971
Ann N Y Acad Sci. 2010 Jun;1199:95-104
pubmed: 20633114
Neurosci Lett. 2020 Jun 11;729:134977
pubmed: 32387718
Eur J Med Res. 2013 Jul 01;18:21
pubmed: 23816364
Neurosurg Focus. 2019 Jul 1;47(1):E21
pubmed: 31261126
J Thromb Haemost. 2018 Jul;16(7):1413-1422
pubmed: 29729651
Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000277
pubmed: 17636626
Sci Rep. 2016 Mar 30;6:23817
pubmed: 27026509
Stroke. 2021 Jan;52(1):20-27
pubmed: 33349011
Nat Commun. 2016 May 18;7:11626
pubmed: 27188843
J Neuroinflammation. 2017 Sep 13;14(1):186
pubmed: 28903766
Exp Neurol. 2014 Nov;261:396-403
pubmed: 25058046
Neurocrit Care. 2011 Apr;14(2):162-7
pubmed: 21125348
Int J Mol Sci. 2018 Apr 19;19(4):
pubmed: 29671828
J Cereb Blood Flow Metab. 2008 Nov;28(11):1761-70
pubmed: 18628782
J Cereb Blood Flow Metab. 1991 Sep;11(5):837-44
pubmed: 1874816
Nat Immunol. 2017 Feb;18(2):132-141
pubmed: 28092376
Shock. 2018 Jun;49(6):704-711
pubmed: 28846566
Acta Neurochir Suppl. 2013;115:233-8
pubmed: 22890674
Stroke. 1992 Sep;23(9):1312-7; discussion 1317-8
pubmed: 1519288
Int J Mol Sci. 2020 Feb 25;21(5):
pubmed: 32106601
Acta Neurochir Suppl. 2016;121:135-9
pubmed: 26463937
Int J Mol Sci. 2020 Jun 29;21(13):
pubmed: 32610502
Biomed Pharmacother. 2021 Jan;133:111048
pubmed: 33378955
Sci Signal. 2017 Feb 07;10(465):
pubmed: 28174280
Neurotherapeutics. 2020 Jan;17(1):294-308
pubmed: 31486022
J Thromb Haemost. 2014 Jun;12(6):943-7
pubmed: 24679129
Acta Neurochir (Wien). 2009 May;151(5):437-46; discussion 446
pubmed: 19296052
Front Neurol. 2018 May 02;9:292
pubmed: 29770118
Stroke. 2010 May;41(5):921-6
pubmed: 20378868
Biomed Res Int. 2014;2014:161702
pubmed: 25110658
J Neuroinflammation. 2020 Aug 14;17(1):239
pubmed: 32795323
Stroke. 2005 May;36(5):1011-5
pubmed: 15790946
Int J Mol Sci. 2018 Jul 13;19(7):
pubmed: 30011792
Front Neurosci. 2019 Nov 15;13:1223
pubmed: 31803007
Transl Neurosci. 2020 Apr 20;11(1):75-86
pubmed: 33335751
Neurosurgery. 2009 Aug;65(2):352-9; discussion 359
pubmed: 19625915
Stroke. 2012 Mar;43(3):683-90
pubmed: 22267829
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004583
pubmed: 16034939
Transl Stroke Res. 2014 Apr;5(2):227-37
pubmed: 24526376
Aging Dis. 2018 Oct 1;9(5):924-937
pubmed: 30271667
J Neuroinflammation. 2014 Jan 03;11:1
pubmed: 24383930
Cells. 2019 May 01;8(5):
pubmed: 31052436
J Neurosurg. 2010 Mar;112(3):681-8
pubmed: 19522571
Neurosurgery. 2000 Mar;46(3):517-30
pubmed: 10719847
BMJ. 1989 Mar 11;298(6674):636-42
pubmed: 2496789
Transl Stroke Res. 2020 Aug 30;:
pubmed: 32862402
J Cereb Blood Flow Metab. 2011 Jun;31(6):1443-51
pubmed: 21285966
Front Pharmacol. 2020 Dec 15;11:595635
pubmed: 33384602
Eur J Pharmacol. 2001 Oct 5;428(2):193-201
pubmed: 11675036
Stroke. 2018 Sep;49(9):2268-2275
pubmed: 30355003
Neurochem Res. 2017 Apr;42(4):1267-1278
pubmed: 28239768
Brain Behav Immun. 2018 Mar;69:190-202
pubmed: 29162556
Transl Neurosci. 2018 Sep 01;9:99-105
pubmed: 30191076
J Neurosurg. 2018 Feb;128(2):515-523
pubmed: 28298024
Circ Res. 2020 Sep 25;127(8):1023-1035
pubmed: 32762491
Acta Neurochir Suppl. 2001;77:145-7
pubmed: 11563274
Life Sci. 2004 Jul 9;75(8):979-89
pubmed: 15193958
Acta Neuropathol. 2015 Aug;130(2):215-31
pubmed: 25956409
Neurol Med Chir (Tokyo). 2001 Apr;41(4):165-75; discussion 175-6
pubmed: 11381675
Circulation. 2007 May 1;115(17):2323-30
pubmed: 17438148
Blood. 2017 Apr 20;129(16):2280-2290
pubmed: 28130211
J Biol Chem. 2007 Jul 13;282(28):20221-9
pubmed: 17502383
Brain Res. 1999 Oct 16;845(1):107-11
pubmed: 10529450
Environ Health Perspect. 1998 Aug;106 Suppl 4:989-94
pubmed: 9703483
J Neuroinflammation. 2019 Jan 15;16(1):8
pubmed: 30646897
J Neuroinflammation. 2018 Jun 9;15(1):178
pubmed: 29885663
Neurocrit Care. 2016 Oct;25(2):205-14
pubmed: 26886010
Neurosurgery. 2003 Feb;52(2):276-81; discussion 281-2
pubmed: 12535355
J Neuroinflammation. 2014 Jun 12;11:106
pubmed: 24924349
J Cereb Blood Flow Metab. 2009 Oct;29(10):1734-41
pubmed: 19584892
Exp Transl Stroke Med. 2013 Apr 25;5(1):6
pubmed: 23618347
Curr Neuropharmacol. 2018;16(9):1385-1395
pubmed: 29651951
Neurosci Lett. 2014 Mar 20;563:160-5
pubmed: 24513235
Neurosurg Rev. 2020 Jun;43(3):825-833
pubmed: 30306357
J Innate Immun. 2018;10(3):215-227
pubmed: 29478057
Transl Stroke Res. 2018 Dec;9(6):654-668
pubmed: 30225551
Front Neurol. 2017 Nov 03;8:565
pubmed: 29163332
Stroke. 2016 Jan;47(1):e11-5
pubmed: 26337970
Curr Treat Options Neurol. 2016 Aug;18(8):38
pubmed: 27325362
Prog Neurobiol. 2012 Apr;97(1):14-37
pubmed: 22414893
Neuroscience. 2012 Nov 8;224:26-37
pubmed: 22902542
Neurochem Res. 2018 Apr;43(4):785-795
pubmed: 29397536
Stroke. 2020 Jul;51(7):2249-2254
pubmed: 32539672
J Neuroinflammation. 2019 Feb 21;16(1):47
pubmed: 30791908
Brain Behav Immun. 2017 Oct;65:125-139
pubmed: 28457811
Neurocrit Care. 2014 Apr;20(2):255-62
pubmed: 24132567
Stroke. 2015 Dec;46(12):3502-6
pubmed: 26486866
Int J Mol Sci. 2016 Apr 02;17(4):497
pubmed: 27049383
Neurol Res. 1995 Apr;17(2):106-8
pubmed: 7609845
J Neuroradiol. 2005 Dec;32(5):348-51
pubmed: 16424838
J Neurosurg. 2005 Jun;102(6):1101-7
pubmed: 16028770
J Neuroinflammation. 2021 Jan 30;18(1):36
pubmed: 33516246
J Thromb Haemost. 2014 Apr;12(4):505-14
pubmed: 24476338
Neurocrit Care. 2020 Oct;33(2):422-428
pubmed: 31898178
Neurosurg Rev. 2018 Oct;41(4):917-930
pubmed: 28215029
Acta Neurochir (Wien). 2010 Dec;152(12):2143-5
pubmed: 20700747
Front Neurosci. 2017 Feb 14;11:37
pubmed: 28261039
Nat Rev Neurol. 2018 Jul;14(7):416-432
pubmed: 29925923
Behav Neurol. 2018 Jun 19;2018:6470957
pubmed: 30018671
Curr Atheroscler Rep. 2017 Oct 23;19(12):50
pubmed: 29063300
J Neuroinflammation. 2017 Jan 21;14(1):18
pubmed: 28109273
Neurol Res. 2018 Aug;40(8):702-708
pubmed: 29688151
Exp Neurol. 2021 Feb;336:113535
pubmed: 33249033
J Cereb Blood Flow Metab. 2015 May;35(5):724-33
pubmed: 25690473
J Cereb Blood Flow Metab. 2012 Mar;32(3):447-55
pubmed: 22146194
Stroke. 2016 May;47(5):1371-3
pubmed: 27056985
Neurosurg Clin N Am. 2010 Apr;21(2):365-79
pubmed: 20380976
J Exp Med. 2008 Sep 1;205(9):2065-74
pubmed: 18695007
Ann Neurol. 2016 Jun;79(6):970-82
pubmed: 27043916
Stroke. 2016 Feb;47(2):490-7
pubmed: 26732571
Drug Discov Today. 2008 Mar;13(5-6):254-60
pubmed: 18342802
J Neurosurg. 1993 Apr;78(4):562-7
pubmed: 8450329
Neurocrit Care. 2019 Jun;30(Suppl 1):46-59
pubmed: 31144274
Stroke. 2017 Aug;48(8):2231-2237
pubmed: 28663512
Front Neurol. 2017 Oct 23;8:555
pubmed: 29109695
BMJ. 2018 Jan 18;360:j5745
pubmed: 29348138
Front Cell Neurosci. 2020 Jul 09;14:210
pubmed: 32754015
J Thromb Haemost. 2012 Apr;10(4):711-3
pubmed: 22309145
Exp Ther Med. 2018 Feb;15(2):1330-1338
pubmed: 29434719
Lancet. 2012 Jul 7;380(9836):44-9
pubmed: 22633825
Aging (Albany NY). 2020 Jun 21;12(14):14849-14862
pubmed: 32575072
Mol Neurobiol. 2017 Jan;54(1):392-405
pubmed: 26742518
Neuropharmacology. 2021 Jun 1;190:108555
pubmed: 33845074
J Exp Med. 2006 Mar 20;203(3):513-8
pubmed: 16533887
Acta Neurochir Suppl. 2020;127:77-81
pubmed: 31407067
Blood. 2011 Nov 10;118(19):5302-11
pubmed: 21821705
J Neuroinflammation. 2013 Jul 13;10:83
pubmed: 23849248
Chin J Traumatol. 2014;17(1):1-7
pubmed: 24506915
J Neuroinflammation. 2017 Feb 20;14(1):39
pubmed: 28219400
Neurol Res. 2006 Jun;28(4):381-98
pubmed: 16759442
Neurochem Res. 2016 Jun;41(6):1496-504
pubmed: 26869040
Exp Neurol. 2021 Feb;336:113532
pubmed: 33245889
Med Gas Res. 2020 Jul-Sep;10(3):103-109
pubmed: 33004706
J Neurosci Res. 2005 Jan 1-15;79(1-2):240-7
pubmed: 15562436
Br J Anaesth. 2012 Sep;109(3):315-29
pubmed: 22879655
Stroke. 1995 Jun;26(6):1086-91; discussion 1091-2
pubmed: 7762027
FASEB J. 2020 Nov;34(11):15080-15092
pubmed: 32918771
Nature. 2016 Jul 27;535(7613):551-5
pubmed: 27466127
Neurosurgery. 2011 Jan;68(1):223-9; discussion 229-30
pubmed: 21099709
J Neuroinflammation. 2018 Dec 20;15(1):347
pubmed: 30572907
Acta Neurochir (Wien). 2002 Nov;144(11):1121-31
pubmed: 12434168
J Neurosurg. 2014 Nov;121(5):1056-62
pubmed: 25148012
Sci Rep. 2016 Nov 24;6:37755
pubmed: 27883038
Nature. 2018 Aug;560(7717):185-191
pubmed: 30046111
Acta Neurochir (Wien). 1985;77(3-4):133-41
pubmed: 2933930
ACS Chem Neurosci. 2021 Feb 3;12(3):430-440
pubmed: 33476129
CNS Neurosci Ther. 2019 Oct;25(10):1096-1112
pubmed: 31583833
Stroke. 2008 Nov;39(11):3015-21
pubmed: 18688013
Isr Med Assoc J. 2002 Nov;4(11):1015-9
pubmed: 12489494
Cytokine. 2020 Sep;133:155142
pubmed: 32485621
Crit Care Med. 2018 Nov;46(11):e1023-e1028
pubmed: 30028365
Stroke. 2012 Sep;43(9):2457-67
pubmed: 22744646
Front Cell Neurosci. 2014 Sep 09;8:269
pubmed: 25249935
Prog Neurobiol. 2013 Feb-Mar;101-102:65-82
pubmed: 23274649
Am J Physiol Heart Circ Physiol. 2016 Apr 1;310(7):H785-801
pubmed: 26825517
J Neuroinflammation. 2020 Feb 25;17(1):74
pubmed: 32098619
Stroke. 2020 Nov;51(11):3320-3331
pubmed: 32933418
Stroke. 2016 Apr;47(4):1165-72
pubmed: 26786115
Brain Circ. 2016 Apr-Jun;2(2):61-66
pubmed: 30276274
Neurocrit Care. 2019 Oct;31(2):373-389
pubmed: 31012056
J Neurol Sci. 2019 Apr 15;399:6-14
pubmed: 30738334
J Cell Mol Med. 2016 Sep;20(9):1770-8
pubmed: 27027405
Curr Drug Targets. 2017;18(12):1399-1407
pubmed: 26343113
Nat Rev Neurol. 2019 Aug;15(8):473-481
pubmed: 31263257
J Neurosurg. 2006 Nov;105(5):723-9
pubmed: 17121134
Lancet Neurol. 2011 Jul;10(7):618-25
pubmed: 21640651
Surg Neurol. 1991 Aug;36(2):112-8
pubmed: 1891755
J Neuroinflammation. 2018 Aug 20;15(1):231
pubmed: 30126439
J Neuroinflammation. 2019 Nov 28;16(1):243
pubmed: 31779639
Circulation. 2010 Apr 6;121(13):1510-7
pubmed: 20308613
Nat Rev Immunol. 2017 Jan;17(1):49-59
pubmed: 27916979
J Cereb Blood Flow Metab. 2009 Apr;29(4):771-9
pubmed: 19156162
Int J Mol Sci. 2021 Feb 28;22(5):
pubmed: 33670976
Ann N Y Acad Sci. 2005 Aug;1053:153-61
pubmed: 16179519
Cell. 1986 Aug 29;46(5):705-16
pubmed: 3091258
Stroke. 2003 Jun;34(6):1382-8
pubmed: 12750537
J Thromb Thrombolysis. 2020 Jan;49(1):67-74
pubmed: 31482326
Crit Care. 2019 Feb 11;23(1):42
pubmed: 30744667
J Neuroimmunol. 2019 Jan 15;326:9-13
pubmed: 30445364
ACS Chem Neurosci. 2019 Jan 16;10(1):412-423
pubmed: 30117729
Stroke. 2012 Jun;43(6):1463-9
pubmed: 22403047
Neurocrit Care. 2010 Apr;12(2):244-51
pubmed: 19967568
Neurosurg Focus. 2019 Jul 1;47(1):E4
pubmed: 31261127
J Neurol Neurosurg Psychiatry. 2017 Apr;88(4):332-338
pubmed: 27927702
Stroke. 2012 May;43(5):1418-21
pubmed: 22343642
J Neurol Sci. 2014 Jul 15;342(1-2):101-6
pubmed: 24819918
Neurol Med Chir (Tokyo). 2011;51(10):679-83
pubmed: 22027241
Nat Rev Mol Cell Biol. 2007 Jan;8(1):49-62
pubmed: 17183360
J Cereb Blood Flow Metab. 2009 Aug;29(8):1444-53
pubmed: 19458605
Brain. 2010 Nov;133(11):3232-42
pubmed: 20736189
Neurol Res. 2006 Oct;28(7):750-8
pubmed: 17164038
World Neurosurg. 2018 Jan;109:e88-e98
pubmed: 28951276
Neurosci Lett. 2005 Apr 18;378(2):82-7
pubmed: 15774262
J Neurosurg. 1996 May;84(5):826-30
pubmed: 8622157
Brain Res Bull. 2020 Jul;160:74-84
pubmed: 32302649
Neuroimmunomodulation. 1995 Jul-Aug;2(4):241-8
pubmed: 8963753
Crit Care Med. 2010 May;38(5):1284-90
pubmed: 20228677
Front Neurosci. 2018 Feb 27;12:96
pubmed: 29535596
Stroke. 2021 Jan;52(1):28-30
pubmed: 33349015