Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant

F98 azaindoles binding affinity brain-penetration fluorine-18 labeling glioblastoma glioma orthotopic positron emission tomography (PET) radiochemistry rat model transmembrane protein 97 σ2 receptor

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
21 May 2021
Historique:
received: 23 04 2021
revised: 18 05 2021
accepted: 18 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 17 6 2021
Statut: epublish

Résumé

The σ

Identifiants

pubmed: 34064122
pii: ijms22115447
doi: 10.3390/ijms22115447
pmc: PMC8196714
pii:
doi:

Substances chimiques

Fluorine Radioisotopes 0
Ligands 0
Radiopharmaceuticals 0
Receptors, sigma 0
Tetrahydroisoquinolines 0
sigma-2 receptor 0
1,2,3,4-tetrahydroisoquinoline 56W89FBX3E
Fluorine-18 GZ5I74KB8G

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : BR 1360/13-1

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Auteurs

Rareş-Petru Moldovan (RP)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.

Daniel Gündel (D)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.

Rodrigo Teodoro (R)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Life Molecular Imaging GmbH, Tegeler Str. 6-7, 13353 Berlin, Germany.

Friedrich-Alexander Ludwig (FA)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.

Steffen Fischer (S)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.

Magali Toussaint (M)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.

Dirk Schepmann (D)

Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster (WWU), Corrensstraße 48, 48149 Münster, Germany.

Bernhard Wünsch (B)

Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster (WWU), Corrensstraße 48, 48149 Münster, Germany.

Peter Brust (P)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
The Lübeck Institute of Experimental Dermatology, University Medical Center Schleswig-Holstein, Ratzeburger Allee 160, 23562 Lübeck, Germany.

Winnie Deuther-Conrad (W)

Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.

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Classifications MeSH