Cyclodextrin Monomers and Polymers for Drug Activity Enhancement.
bioactivity
cyclodextrins
drug
enhancers
polymers
review
stability
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
14
04
2021
revised:
18
05
2021
accepted:
19
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Cyclodextrins (CDs) and cyclodextrin (CD)-based polymers are well-known complexing agents. One of their distinctive features is to increase the quantity of a drug in a solution or improve its delivery. However, in certain instances, the activity of the solutions is increased not only due to the increase of the drug dose but also due to the drug complexation. Based on numerous studies reviewed, the drug appeared more active in a complex form. This review aims to summarize the performance of CDs and CD-based polymers as activity enhancers. Accordingly, the review is divided into two parts, i.e., the effect of CDs as active drugs and as enhancers in antimicrobials, antivirals, cardiovascular diseases, cancer, neuroprotective agents, and antioxidants.
Identifiants
pubmed: 34064190
pii: polym13111684
doi: 10.3390/polym13111684
pmc: PMC8196804
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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