Coupling Additive Manufacturing with Hot Melt Extrusion Technologies to Validate a Ventilator-Associated Pneumonia Mouse Model.
Staphylococcus aureus
additive manufacturing
anti-infective
antibiofilm
biomaterials
ciprofloxacin
endotracheal tubes
extrusion die
extrusion nozzle
hot melt extrusion
medical devices
ventilator-associated pneumonia
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
30
03
2021
revised:
08
05
2021
accepted:
18
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Additive manufacturing is widely used to produce highly complex structures. Moreover, this technology has proven its superiority in producing tools which can be used in different applications. We designed and produced an extrusion nozzle that allowed us to hot melt extrude drug-loaded tubes. The tubes were an essential part of a new mouse ventilator-associated pneumonia (VAP) model. Ciprofloxacin (CPX) was selected for its expected activity against the pathogen
Identifiants
pubmed: 34064276
pii: pharmaceutics13060772
doi: 10.3390/pharmaceutics13060772
pmc: PMC8224298
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 722467
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