Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study.

adrenaline adrenergic regulation cardiovascular risk cardiovascular system catecholamine noradrenaline

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
04 May 2021
Historique:
received: 29 03 2021
revised: 28 04 2021
accepted: 29 04 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients submitted to the evaluation of urine metanephrines at the City of Health and Science University Hospital of Turin between 2007 and 2015, mainly for investigating the suspicion of secondary hypertension or the secretion of an adrenal lesion. The univariate analysis showed associations between metanephrines and cardiometabolic variables/parameters, particularly considering noradrenaline metabolite. At univariate regression, normetanephrine was associated with hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.11-1.25;

Identifiants

pubmed: 34064307
pii: jcm10091967
doi: 10.3390/jcm10091967
pmc: PMC8125207
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Mirko Parasiliti-Caprino (M)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Chiara Obert (C)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Chiara Lopez (C)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Martina Bollati (M)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Fabio Bioletto (F)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Chiara Bima (C)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Filippo Egalini (F)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Alessandro Maria Berton (AM)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Nunzia Prencipe (N)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Fabio Settanni (F)

Clinical Biochemistry Laboratory, City of Health and Science University Hospital, 10126 Turin, Italy.

Valentina Gasco (V)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Giulio Mengozzi (G)

Clinical Biochemistry Laboratory, City of Health and Science University Hospital, 10126 Turin, Italy.

Ezio Ghigo (E)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Mauro Maccario (M)

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.

Classifications MeSH