Platelet-Expressed Synaptophysin (pSyn) as Novel Biomarker in Neuroendocrine Malignancies.
biomarker
neuroendocrine malignancies
platelets
synaptophysin
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 May 2021
11 May 2021
Historique:
received:
31
03
2021
revised:
29
04
2021
accepted:
07
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Neuroendocrine neoplasms (NENs) encompass a heterogeneous group of tumors. Whereas low-grade neuroendocrine tumors (NETs) are histologically well-differentiated, highly aggressive neuroendocrine carcinomas (NECs) are characterized by a high proliferation rate and a worse clinical outcome. Since most NEN patients need monitoring of tumor progress and response to treatment for a long period of time, especially in metastatic disease, reliable, dynamic, and easy-to-assess biomarkers are needed. In this prospective study, we identified platelet-expressed synaptophysin (pSyn) as a novel biomarker in NENs. The level of pSyn in NENs was significantly upregulated compared to healthy donors. pSyn was positively correlated with higher tumor stages, the occurrence of metastasis, histological grading, and higher tumor proliferation (Ki67). Most importantly, high pSyn expression in our NEN cohort was shown to predict shorter progression-free survival (PFS). In conclusion, our data highlight the potential of pSyn as a novel biomarker in NENs reflecting tumor stages, grading, and prognosis.
Identifiants
pubmed: 34064565
pii: cancers13102286
doi: 10.3390/cancers13102286
pmc: PMC8150833
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Germany's Excellence Strategy - EXC 2180 - 39090067
Organisme : Deutsche Forschungsgemeinschaft
ID : 374031971-TRR 240/project B05
Références
Eur Heart J. 2002 Jun;23(12):967-74
pubmed: 12069452
Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):28-37
pubmed: 26627724
Hematol Oncol Clin North Am. 2016 Feb;30(1):1-19
pubmed: 26614366
Urol Oncol. 2018 Apr;36(4):162.e1-162.e6
pubmed: 29289429
J Nucl Med. 2017 Sep;58(9):1452-1458
pubmed: 28280220
J Leukoc Biol. 2009 Jan;85(1):81-7
pubmed: 18832606
Cancer Cell. 2015 Nov 9;28(5):666-676
pubmed: 26525104
Neuroendocrinology. 2014;100(4):265-77
pubmed: 25300695
Endocrinol Metab Clin North Am. 2018 Sep;47(3):485-504
pubmed: 30098712
Am J Surg Pathol. 2013 Nov;37(11):1671-7
pubmed: 24121170
J Thorac Oncol. 2015 Sep;10(9):1243-1260
pubmed: 26291008
Blood. 2016 Jul 7;128(1):24-31
pubmed: 27154188
Cancer Res. 2020 Apr 1;80(7):1371-1373
pubmed: 32075797
HPB (Oxford). 2019 May;21(5):612-618
pubmed: 30366884
Histopathology. 2020 Jan;76(2):182-188
pubmed: 31433515
J Neurosci. 1999 Mar 15;19(6):1922-31
pubmed: 10066245
J Obstet Gynaecol. 2014 Aug;34(6):515-8
pubmed: 24832894
Oncoimmunology. 2017 Nov 27;7(2):e1364827
pubmed: 29308299
Neuron. 2011 Jun 9;70(5):847-54
pubmed: 21658579
Neuroendocrinology. 2017 Feb 11;105(3):196-200
pubmed: 28190015
Nat Rev Cancer. 2011 Feb;11(2):123-34
pubmed: 21258396
World J Gastroenterol. 2019 Nov 7;25(41):6248-6257
pubmed: 31749595
Cancer Res. 2018 Jul 1;78(13):3407-3412
pubmed: 29921699
Cancer Immunol Immunother. 2021 Feb 4;:
pubmed: 33538861
Kidney Int. 1990 Mar;37(3):955-64
pubmed: 2313983
Clin Cancer Res. 2016 Feb 15;22(4):1011-7
pubmed: 26482044
Front Oncol. 2021 Mar 17;11:642170
pubmed: 33816291
Clin Cancer Res. 2008 Dec 1;14(23):7798-803
pubmed: 19047107
Hum Pathol. 1986 Oct;17(10):979-83
pubmed: 3093369
Eur J Intern Med. 2011 Dec;22(6):e95-8
pubmed: 22075321
J Clin Endocrinol Metab. 1997 Aug;82(8):2622-8
pubmed: 9253344
Cancers (Basel). 2019 Feb 26;11(3):
pubmed: 30813611
Proc Natl Acad Sci U S A. 1986 May;83(10):3500-4
pubmed: 3010302
Int J Mol Med. 2011 Aug;28(2):223-9
pubmed: 21491079
Neuroendocrinology. 2014;100(2-3):240-9
pubmed: 25428270
Neuroendocrinology. 2004;80 Suppl 1:12-5
pubmed: 15477709
Front Oncol. 2020 Aug 12;10:1627
pubmed: 32903345
Am J Surg Pathol. 2015 May;39(5):683-90
pubmed: 25723112
Endocr Connect. 2016 Sep;5(5):174-87
pubmed: 27582247
Nat Med. 2017 Jun 6;23(6):1-10
pubmed: 28586335
Front Immunol. 2019 Jul 31;10:1805
pubmed: 31417569
Cancer Res. 2012 Jan 15;72(2):440-8
pubmed: 22127925
Neuroendocrinology. 2018;107(1):73-90
pubmed: 29566385
Digestion. 2011;84(1):22-8
pubmed: 21304238
Nucl Med Commun. 2002 Aug;23(8):727-34
pubmed: 12124477