Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children's Hospital.
best practice alerts (BPAs)
clinical decision support (CDS)
electronic health records (EHR)
genomic indicators
genotype
pediatrics
pharmacogenomics (PGx)
phenotype
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
11 May 2021
11 May 2021
Historique:
received:
31
03
2021
revised:
03
05
2021
accepted:
06
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Pharmacogenomics (PGx) is a growing field within precision medicine. Testing can help predict adverse events and sub-therapeutic response risks of certain medications. To date, the US FDA lists over 280 drugs which provide biomarker-based dosing guidance for adults and children. At Arkansas Children's Hospital (ACH), a clinical PGx laboratory-based test was developed and implemented to provide guidance on 66 pediatric medications for genotype-guided dosing. This PGx test consists of 174 single nucleotide polymorphisms (SNPs) targeting 23 clinically actionable PGx genes or gene variants. Individual genotypes are processed to provide per-gene discrete results in star-allele and phenotype format. These results are then integrated into EPIC- EHR. Genomic indicators built into EPIC-EHR provide the source for clinical decision support (CDS) for clinicians, providing genotype-guided dosing.
Identifiants
pubmed: 34064668
pii: jpm11050394
doi: 10.3390/jpm11050394
pmc: PMC8150685
pii:
doi:
Types de publication
Journal Article
Langues
eng
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