Regulation of Tissue Inflammation by 12-Lipoxygenases.
12-LOXs
12-lipoxygenases
12/15-LOX
12/15-lipoxygenase
eicosanoids
inflammation
lipoxygenases
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
30
03
2021
revised:
03
05
2021
accepted:
07
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
6
10
2021
Statut:
epublish
Résumé
Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12-LOXs) primarily oxygenate the 12th carbon of its substrates. Many studies have demonstrated that 12-LOXs and their eicosanoid metabolite 12-hydroxyeicosatetraenoate (12-HETE), have significant pathological implications in inflammatory diseases. Increased level of 12-LOX activity promotes stress (both oxidative and endoplasmic reticulum)-mediated inflammation, leading to damage in these tissues. 12-LOXs are also associated with enhanced cellular migration of immune cells-a characteristic of several metabolic and autoimmune disorders. Genetic depletion or pharmacological inhibition of the enzyme in animal models of various diseases has shown to be protective against disease development and/or progression in animal models in the setting of diabetes, pulmonary, cardiovascular, and metabolic disease, suggesting a translational potential of targeting the enzyme for the treatment of several disorders. In this article, we review the role of 12-LOXs in the pathogenesis of several diseases in which chronic inflammation plays an underlying role.
Identifiants
pubmed: 34064822
pii: biom11050717
doi: 10.3390/biom11050717
pmc: PMC8150372
pii:
doi:
Substances chimiques
Arachidonate 12-Lipoxygenase
EC 1.13.11.31
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK105588
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020595
Pays : United States
Organisme : NCATS NIH HHS
ID : R03 TR003381
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127786
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK060581
Pays : United States
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