Final Exon Frameshift Biallelic

ESCRT HSP PTPN23 hereditary spastic paraplegia protein tyrosine phosphatase

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
11 May 2021
Historique:
received: 12 04 2021
revised: 04 05 2021
accepted: 06 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

The hereditary spastic paraplegias (HSPs) are a large clinically heterogeneous group of genetic disorders classified as 'pure' when the cardinal feature of progressive lower limb spasticity and weakness occurs in isolation and 'complex' when associated with other clinical signs. Here, we identify a homozygous frameshift alteration occurring in the last coding exon of the protein tyrosine phosphatase type 23 (

Identifiants

pubmed: 34064836
pii: brainsci11050614
doi: 10.3390/brainsci11050614
pmc: PMC8151426
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Medical Research Council
ID : G1002279
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15054
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15047
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220600/Z/20/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_18047
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001931
Pays : United Kingdom

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Auteurs

Reham Khalaf-Nazzal (R)

Biomedical Sciences Department, Faculty of Medicine, Arab American University of Palestine, Jenin P227, Palestine.

James Fasham (J)

College of Medicine and Health, RILD Wellcome Wolfson Centre, University of Exeter, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.
Peninsula Clinical Genetics Service, Royal Devon & Exeter Hospital (Heavitree), Gladstone Road, Exeter EX1 2ED, UK.

Nishanka Ubeyratna (N)

College of Medicine and Health, RILD Wellcome Wolfson Centre, University of Exeter, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.

David J Evans (DJ)

Exeter Genomics Laboratory, Royal Devon & Exeter NHS Foundation Trust, Exeter EX2 5DW, UK.

Joseph S Leslie (JS)

College of Medicine and Health, RILD Wellcome Wolfson Centre, University of Exeter, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.

Thomas T Warner (TT)

Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, UK.

Fida' Al-Hijawi (F)

Paediatrics' Community Outpatient Clinics, Palestinian Ministry of Health, Jenin P200, Palestine.

Shurouq Alshaer (S)

Faculty of Graduate Studies, Arab American University, Ramallah P622, Palestine.

Wisam Baker (W)

Paediatrics Department, Dr. Khalil Suleiman Government Hospital, Jenin P200, Palestine.

Peter D Turnpenny (PD)

College of Medicine and Health, RILD Wellcome Wolfson Centre, University of Exeter, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.
Peninsula Clinical Genetics Service, Royal Devon & Exeter Hospital (Heavitree), Gladstone Road, Exeter EX1 2ED, UK.

Emma L Baple (EL)

College of Medicine and Health, RILD Wellcome Wolfson Centre, University of Exeter, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.
Peninsula Clinical Genetics Service, Royal Devon & Exeter Hospital (Heavitree), Gladstone Road, Exeter EX1 2ED, UK.

Andrew H Crosby (AH)

College of Medicine and Health, RILD Wellcome Wolfson Centre, University of Exeter, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.

Classifications MeSH