Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial.

PREDIMED study atrial fibrillation glycolysis heart failure

Journal

Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790

Informations de publication

Date de publication:
11 May 2021
Historique:
received: 08 04 2021
revised: 06 05 2021
accepted: 07 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

The increased prevalence of atrial fibrillation (AF) and heart failure (HF) highlights the need to better understand the mechanisms underlying these cardiovascular diseases (CVDs). In the present study, we aimed to evaluate the association between glycolysis-related metabolites and the risk of AF and HF in a Mediterranean population at high risk of CVD. We used two case-control studies nested within the PREDIMED trial. A total of 512 incident AF cases matched to 734 controls, and 334 incident HF cases matched to 508 controls, were included. Plasma metabolites were quantified by using hydrophilic interaction liquid chromatography coupled with high-resolution negative ion mode MS detection. Conditional logistic regression analyses were performed. The results showed no association between baseline plasma glycolysis intermediates and other related metabolites with AF. Only phosphoglycerate was associated with a higher risk of HF (OR

Identifiants

DOI: 10.3390/metabo11050306 PMID: 34064960 PMC: PMC8151758
pubmed: 34064960
pii: metabo11050306
doi: 10.3390/metabo11050306
pmc: PMC8151758
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Instituto de Salud Carlos III
ID : CNIC-06/2007
Organisme : Instituto de Salud Carlos III
ID : AGL2010-22319-C03-03
Organisme : Generalitat Valenciana
ID : ACOMP/2012/190
Organisme : Instituto de Salud Carlos III
ID : PI11/02505
Organisme : NHLBI NIH HHS
ID : R01 HL118264
Pays : United States
Organisme : Generalitat Valenciana
ID : PROMETEO 17/2017
Organisme : Instituto de Salud Carlos III
ID : RTIC G03/140
Organisme : Generalitat Valenciana
ID : ACOMP/2013/159
Organisme : NIH HHS
ID : R01HL118264
Pays : United States
Organisme : Generalitat Valenciana
ID : ACOMP/213/165
Organisme : Instituto de Salud Carlos III
ID : SAF2016-80532
Organisme : Generalitat Valenciana
ID : AP111/10
Organisme : Instituto de Salud Carlos III
ID : THEMATIC NETWORK "PREDIMED", RD 06/0045
Organisme : Instituto de Salud Carlos III
ID : SAF2009-12304
Organisme : Generalitat Valenciana
ID : ACOM2011/145
Organisme : Generalitat Valenciana
ID : AP-042/11
Organisme : Instituto de Salud Carlos III
ID : CIBER 06/03
Organisme : Instituto de Salud Carlos III
ID : PI06-1326
Organisme : Generalitat Valenciana
ID : ACOMP2010-181
Organisme : Instituto de Salud Carlos III
ID : PI07-0954

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Auteurs

Nerea Becerra-Tomás (N)

Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain.
Universitat Rovira i Virgili, Departament of Biochemistry and Biotechnology, Human Nutrition Unit, 43201 Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain.
Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
ORCID: 0000-0002-4429-6507

Miguel Ruiz-Canela (M)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
ORCID: 0000-0002-7684-2787

Pablo Hernández-Alonso (P)

Universitat Rovira i Virgili, Departament of Biochemistry and Biotechnology, Human Nutrition Unit, 43201 Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain.
Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, University of Malaga (IBIMA), 29010 Malaga, Spain.
ORCID: 0000-0002-9977-8976

Mònica Bulló (M)

Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain.
Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), 43201 Reus, Spain.
ORCID: 0000-0002-0218-7046

Jun Li (J)

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.

Marta Guasch-Ferré (M)

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Channing Division for Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-8525-1404

Estefanía Toledo (E)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
ORCID: 0000-0002-6263-4434

Clary B Clish (CB)

The Broad Institute of Harvard and MIT, Boston, MA 02142, USA.

Ramon Estruch (R)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain.
ORCID: 0000-0003-1260-4445

Emilio Ros (E)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Lipid Clinic, Department of Endocrinology and Nutrition, IDIBAPS, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain.

Montserrat Fitó (M)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Cardiovascular and Nutrition Research Group, Institut de Recerca Hospital del Mar, 08036 Barcelona, Spain.

Chih-Hao Lee (CH)

Department of Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA 02132, USA.

Kerry Pierce (K)

The Broad Institute of Harvard and MIT, Boston, MA 02142, USA.

Fernando Arós (F)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Cardiology, University Hospital of Alava, 01009 Vitoria, Spain.

Lluís Serra-Majem (L)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria and Service of Preventive Medicine, Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canary Health Service, 35001 Las Palmas de Gran Canaria, Spain.
ORCID: 0000-0002-9658-9061

Liming Liang (L)

Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.

Cristina Razquin (C)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
ORCID: 0000-0003-3480-2645

Enrique Gómez-Gracia (E)

Department of Preventive Medicine and Public Health, School of Medicine, University of Málaga, 29010 Málaga, Spain.

Miguel A Martínez-González (MA)

Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
ORCID: 0000-0002-3917-9808

Frank B Hu (FB)

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Channing Division for Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Dolores Corella (D)

Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain.
Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
ORCID: 0000-0002-2366-4104

Jordi Salas-Salvadó (J)

Universitat Rovira i Virgili, Departament of Biochemistry and Biotechnology, Human Nutrition Unit, 43201 Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain.
Consorcio Centro de Investigaciones Biomédicas en Red, M.P (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Nutrition Unit, University Hospital of Sant Joan de Reus, 43204 Reus, Spain.
ORCID: 0000-0003-2700-7459

Classifications MeSH