Siglec Ligands.
B cells
NK cells
eosinophils
immune checkpoint
macrophages
mast cells
microglia
monocytes
myelin associated glycoprotein
neutrophils
sialic acid
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
20 05 2021
20 05 2021
Historique:
received:
16
04
2021
revised:
14
05
2021
accepted:
17
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
9
11
2021
Statut:
epublish
Résumé
A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan contexts, as their outermost sugar moiety. Among their functions, glycans engage complementary glycan binding proteins (lectins) to regulate cell physiology. Among the glycan binding proteins are the Siglecs, sialic acid binding immunoglobulin-like lectins. In humans, there are 14 Siglecs, most of which are expressed on overlapping subsets of immune system cells. Each Siglec engages distinct, endogenous sialylated glycans that initiate signaling programs and regulate cellular responses. Here, we explore the emerging science of Siglec ligands, including endogenous sialoglycoproteins and glycolipids and synthetic sialomimetics. Knowledge in this field promises to reveal new molecular pathways controlling cell physiology and new opportunities for therapeutic intervention.
Identifiants
pubmed: 34065256
pii: cells10051260
doi: 10.3390/cells10051260
pmc: PMC8161119
pii:
doi:
Substances chimiques
Carrier Proteins
0
Glycolipids
0
Glycoproteins
0
Ligands
0
Polysaccharides
0
Sialic Acid Binding Immunoglobulin-like Lectins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : U19 AI136443
Pays : United States
Organisme : Flight Attendant Medical Research Institute
ID : 042337
Organisme : NHLBI NIH HHS
ID : K12 HL141952
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA241953
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG068089
Pays : United States
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