The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu.
FGF signaling
FGF23
Wnt pathway
cardiomyocyte
klotho
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
20 05 2021
20 05 2021
Historique:
received:
10
04
2021
revised:
13
05
2021
accepted:
17
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.
Identifiants
pubmed: 34065339
pii: cells10051266
doi: 10.3390/cells10051266
pmc: PMC8161087
pii:
doi:
Substances chimiques
Biomarkers
0
FGF23 protein, human
0
Fibroblast Growth Factors
62031-54-3
Fibroblast Growth Factor-23
7Q7P4S7RRE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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