Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi.
Aspergillus spp.
Candida auris
antifungals
drug repurposing
emerging fungi
multidrug resistance
new targets
repositioning
therapeutic alternatives
yeasts
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
20 May 2021
20 May 2021
Historique:
received:
12
03
2021
revised:
13
05
2021
accepted:
18
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Immunodepression, whether due to HIV infection or organ transplantation, has increased human vulnerability to fungal infections. These conditions have created an optimal environment for the emergence of opportunistic infections, which is concomitant to the increase in antifungal resistance. The use of conventional antifungal drugs as azoles and polyenes can lead to clinical failure, particularly in immunocompromised individuals. Difficulties related to treating fungal infections combined with the time required to develop new drugs, require urgent consideration of other therapeutic alternatives. Drug repurposing is one of the most promising and rapid solutions that the scientific and medical community can turn to, with low costs and safety advantages. To treat life-threatening resistant fungal infections, drug repurposing has led to the consideration of well-known and potential molecules as a last-line therapy. The aim of this review is to provide a summary of current antifungal compounds and their main resistance mechanisms, following by an overview of the antifungal activity of non-traditional antimicrobial drugs. We provide their eventual mechanisms of action and the synergistic combinations that improve the activity of current antifungal treatments. Finally, we discuss drug repurposing for the main emerging multidrug resistant (MDR) fungus, including the
Identifiants
pubmed: 34065420
pii: ph14050488
doi: 10.3390/ph14050488
pmc: PMC8161392
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Metabolites. 2020 Mar 12;10(3):
pubmed: 32178468
J Pharm Pharmacol. 1989 Mar;41(3):160-3
pubmed: 2568441
Antibiotics (Basel). 2020 Nov 15;9(11):
pubmed: 33203147
Antimicrob Agents Chemother. 2021 Mar 18;65(4):
pubmed: 33468482
Virulence. 2017 Feb 17;8(2):138-142
pubmed: 27268469
Mol Biosyst. 2005 Jul;1(2):127-34
pubmed: 16880974
J Appl Microbiol. 2020 Oct;129(4):860-875
pubmed: 32320111
Int J Antimicrob Agents. 2019 Oct;54(4):518-523
pubmed: 31173863
J Mycol Med. 2019 Sep;29(3):253-259
pubmed: 31399349
Drug Discov Today Technol. 2014 Mar;11:65-71
pubmed: 24847655
J S Afr Vet Assoc. 1999 Jun;70(2):61-70
pubmed: 10855824
Pharmacoepidemiol Drug Saf. 2005 Nov;14(11):755-67
pubmed: 15654717
J Glob Antimicrob Resist. 2020 Jun;21:314-317
pubmed: 32004725
Open Forum Infect Dis. 2020 Jan 12;7(2):ofaa016
pubmed: 32099843
Philos Trans R Soc Lond B Biol Sci. 2016 Dec 5;371(1709):
pubmed: 28080986
Curr Opin Microbiol. 2017 Dec;40:58-64
pubmed: 29132066
Fungal Genet Biol. 2019 Oct;131:103243
pubmed: 31228646
Mycoses. 2007 Jul;50(4):270-6
pubmed: 17576318
Clin Cancer Res. 2015 Aug 1;21(15):3462-3470
pubmed: 25862759
PLoS One. 2017 Feb 2;12(2):e0171145
pubmed: 28151949
Med Mycol. 2021 May 4;59(5):476-485
pubmed: 32823281
Methods Protoc. 2019 Apr 17;2(2):
pubmed: 31164611
mSphere. 2019 Jan 23;4(1):
pubmed: 30674648
Clin Pharmacol Ther. 2010 Mar;87(3):272-7
pubmed: 20130567
Antimicrob Resist Infect Control. 2019 Apr 24;8:66
pubmed: 31044071
FEMS Microbiol Lett. 2006 Sep;262(1):9-13
pubmed: 16907733
Int J Antimicrob Agents. 2019 Oct;54(4):507-512
pubmed: 31299296
Clin Microbiol Rev. 1999 Oct;12(4):501-17
pubmed: 10515900
Sci Transl Med. 2012 Dec 19;4(165):165rv13
pubmed: 23253612
Rev Med Suisse. 2005 Jun 29;1(26):1728-30, 1732-3
pubmed: 16117046
ACS Infect Dis. 2020 May 8;6(5):768-786
pubmed: 31550886
J Appl Microbiol. 2020 Feb;128(2):426-437
pubmed: 31621139
ACS Infect Dis. 2020 Nov 13;6(11):2950-2958
pubmed: 33141557
Lancet Infect Dis. 2019 Aug;19(8):843-851
pubmed: 31345462
Antimicrob Agents Chemother. 2020 Mar 24;64(4):
pubmed: 31988099
Antimicrob Agents Chemother. 2018 Sep 24;62(10):
pubmed: 30104269
Braz J Infect Dis. 2013 Jul-Aug;17(4):395-400
pubmed: 23602464
Microbiologyopen. 2018 Aug;7(4):e00578
pubmed: 29345117
Front Cell Infect Microbiol. 2019 Jun 11;9:193
pubmed: 31245302
Expert Rev Anti Infect Ther. 2015 Jun;13(6):787-98
pubmed: 25843556
Expert Rev Anti Infect Ther. 2020 Jul;18(7):609-612
pubmed: 32290720
Antimicrob Agents Chemother. 2009 Aug;53(8):3337-46
pubmed: 19487443
Future Microbiol. 2021 Jan;16:71-81
pubmed: 33459560
Am J Ther. 2020 Sep/Oct;27(5):e528-e532
pubmed: 31082830
mBio. 2020 Nov 24;11(6):
pubmed: 33234685
Front Microbiol. 2018 Oct 25;9:2541
pubmed: 30410476
Lancet Infect Dis. 2016 Oct;16(10):1111-1112
pubmed: 27676347
J Med Microbiol. 2020 Oct;69(10):1221-1227
pubmed: 32894212
Med Mycol. 2017 Jan 1;55(1):118-124
pubmed: 27562862
Antimicrob Agents Chemother. 2020 Dec 16;65(1):
pubmed: 33046487
Antimicrob Agents Chemother. 2020 Aug 20;64(9):
pubmed: 32571823
Microorganisms. 2020 Apr 23;8(4):
pubmed: 32340403
Nat Rev Drug Discov. 2019 Jan;18(1):41-58
pubmed: 30310233
Folia Microbiol (Praha). 2016 Sep;61(5):399-403
pubmed: 26847460
Int J Antimicrob Agents. 2007 Oct;30(4):297-308
pubmed: 17629679
Clin Infect Dis. 2006 Mar 1;42(5):657-68
pubmed: 16447111
Int J Antimicrob Agents. 2018 Mar;51(3):333-339
pubmed: 28890395
Intern Med J. 2007 Jul;37(7):495-8
pubmed: 17547727
Clin Microbiol Infect. 2016 Aug;22(8):670-80
pubmed: 26812445
Curr Opin Microbiol. 2000 Aug;3(4):349-53
pubmed: 10972492
J Cutan Pathol. 2009 Oct;36 Suppl 1:39-41
pubmed: 19775393
Gastroenterol Hepatol (N Y). 2007 Mar;3(3):218-25
pubmed: 21960835
J Appl Microbiol. 2020 Jan;128(1):88-101
pubmed: 31509623
Antimicrob Agents Chemother. 2014 Oct;58(10):5855-62
pubmed: 25049253
Case Rep Pulmonol. 2011;2011:917089
pubmed: 22937433
J Infect Chemother. 2020 Mar;26(3):309-311
pubmed: 31678053
Biochem Biophys Res Commun. 2004 Sep 17;322(2):520-5
pubmed: 15325261
ACS Infect Dis. 2021 Feb 12;7(2):377-389
pubmed: 33471513
Clin Microbiol Infect. 2014 Apr;20 Suppl 3:27-46
pubmed: 24548001
J Exp Clin Cancer Res. 2020 May 12;39(1):86
pubmed: 32398164
Med Mycol. 2015 Nov;53(8):890-5
pubmed: 26316212
J Chemother. 2004 Apr;16(2):134-8
pubmed: 15216946
Clin Microbiol Infect. 2016 May;22(5):423-7
pubmed: 27050666
Ann N Y Acad Sci. 2019 Jan;1435(1):57-78
pubmed: 29762860
Int J Antimicrob Agents. 2014 Jan;43(1):86-91
pubmed: 24156913
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4799-808
pubmed: 27246782
Virulence. 2020 Dec;11(1):1466-1481
pubmed: 33100149
Br J Haematol. 2014 Aug;166(4):471-84
pubmed: 24749533
Mycopathologia. 2019 Oct;184(5):615-623
pubmed: 31359292
Med Mycol. 2020 Nov 10;58(8):1037-1043
pubmed: 32415846
Clin Infect Dis. 2008 Jan 1;46(1):120-8
pubmed: 18171227
Nat Rev Drug Discov. 2017 Sep;16(9):603-616
pubmed: 28496146
Med Mycol. 2018 Apr 1;56(suppl_1):102-125
pubmed: 29538735
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12040-12045
pubmed: 30389707
Antimicrob Agents Chemother. 1995 Dec;39(12):2610-4
pubmed: 8592988
Haematologica. 2006 Aug;91(8):1068-75
pubmed: 16885047
Recent Results Cancer Res. 2013;191:39-65
pubmed: 22893199
PLoS Genet. 2012;8(11):e1003083
pubmed: 23209439
Rev Iberoam Micol. 2007 Mar;24(1):3-13
pubmed: 17592884
J Med Microbiol. 2000 Sep;49(9):831-840
pubmed: 10966233
Mycoses. 2021 Mar;64(3):232-244
pubmed: 33098146
Antimicrob Agents Chemother. 2014;58(2):1055-62
pubmed: 24277040
Presse Med. 1993 Feb 6;22(4):157-60
pubmed: 8493226
Front Microbiol. 2017 Mar 28;8:535
pubmed: 28400768
J Antibiot (Tokyo). 2021 May;74(5):346-353
pubmed: 33469194
Lancet Infect Dis. 2002 Sep;2(9):550-63
pubmed: 12206971
Eur J Clin Microbiol Infect Dis. 2017 Jun;36(6):923-924
pubmed: 28150046
Clin Drug Investig. 2018 Aug;38(8):653-671
pubmed: 29737455
Infection. 2018 Apr;46(2):253-257
pubmed: 29159502
Mycoses. 2015 Jun;58 Suppl 2:2-13
pubmed: 26033251
Curr Top Med Chem. 2018;18(15):1324-1332
pubmed: 30277156
Eur J Med Chem. 2017 Oct 20;139:12-21
pubmed: 28797882
Nat Rev Microbiol. 2016 Feb;14(2):106-17
pubmed: 26685750
J Med Microbiol. 2021 Mar;70(3):
pubmed: 33560202
Lancet Infect Dis. 2017 Dec;17(12):e383-e392
pubmed: 28774698
Pathogens. 2021 Feb 03;10(2):
pubmed: 33546137
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S604-11
pubmed: 26567277
J Fungi (Basel). 2019 Jul 01;5(3):
pubmed: 31266196
Int J Antimicrob Agents. 2017 Jun;49(6):695-702
pubmed: 28450174
Antimicrob Agents Chemother. 2012 Jul;56(7):3758-66
pubmed: 22508310
Trends Microbiol. 2014 Mar;22(3):120-7
pubmed: 24530175
J Mycol Med. 2021 Mar;31(1):101080
pubmed: 33278803
mBio. 2018 Dec 18;9(6):
pubmed: 30563895
Annu Rev Microbiol. 2015;69:71-92
pubmed: 26488273
Rev Iberoam Micol. 2019 Jan - Mar;36(1):44-47
pubmed: 30691952
Molecules. 2019 Oct 15;24(20):
pubmed: 31619024
J Infect Chemother. 2021 May;27(5):696-701
pubmed: 33358402
PLoS One. 2015 May 27;10(5):e0125927
pubmed: 26016941
J Gen Appl Microbiol. 2013;59(2):167-70
pubmed: 23759870
Infect Dis Clin North Am. 2016 Mar;30(1):51-83
pubmed: 26739608
mBio. 2014 Feb 11;5(1):e00765-13
pubmed: 24520056
Wellcome Open Res. 2019 Jan 22;4:8
pubmed: 30801037
Antimicrob Agents Chemother. 2014 Dec;58(12):7501-9
pubmed: 25288082
Mycoses. 2019 Aug;62(8):620-637
pubmed: 30773703
J Antibiot (Tokyo). 2018 Nov;71(12):978-991
pubmed: 30242283
Antimicrob Agents Chemother. 2016 Sep 23;60(10):5663-72
pubmed: 27401577
Nihon Ishinkin Gakkai Zasshi. 2007;48(3):109-13
pubmed: 17667894
Biomed Pharmacother. 2017 May;89:1422-1430
pubmed: 28346993
mSphere. 2019 Jul 31;4(4):
pubmed: 31366705
Mycoses. 2011 Nov;54(6):e737-43
pubmed: 21605196
Med Mycol. 2019 Apr 1;57(3):387-390
pubmed: 29762783
Antimicrob Agents Chemother. 2019 Sep 23;63(10):
pubmed: 31307986
Int J Antimicrob Agents. 2016 Dec;48(6):583-591
pubmed: 27524102
PeerJ. 2018 May 4;6:e4761
pubmed: 29740519
Front Microbiol. 2017 Jan 23;8:36
pubmed: 28167935