Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics.

Acetylation Brain Neoplasms / enzymology Computer Simulation Glioblastoma / enzymology Glioma / enzymology Humans Isocitrate Dehydrogenase / metabolism Mutagenesis, Site-Directed Mutation Protein Processing, Post-Translational Recombinant Proteins / isolation & purification Structure-Activity Relationship
IDH1 acetylation kinetics post-translational modification

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
16 05 2021
Historique:
received: 12 03 2021
revised: 10 05 2021
accepted: 12 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 8 10 2021
Statut: epublish

Résumé

Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP

Identifiants

DOI: 10.3390/biom11050740 PMID: 34065652 PMC: PMC8157008
pubmed: 34065652
pii: biom11050740
doi: 10.3390/biom11050740
pmc: PMC8157008
pii:
doi:

Substances chimiques

Recombinant Proteins 0
Isocitrate Dehydrogenase EC 1.1.1.41
IDH1 protein, human EC 1.1.1.42.

Types de publication

Evaluation Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM137773
Pays : United States
Organisme : NIH HHS
ID : 5T34GM008303
Pays : United States
Organisme : American Cancer Society
ID : 133484-RSG-19-075-01-TBE
Organisme : NIH HHS
ID : 5R25GM058906
Pays : United States
Organisme : NIH HHS
ID : R35 GM137773
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA132384
Pays : United States

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Auteurs

Joi Weeks (J)

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.

Alexandra I Strom (AI)

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.

Vinnie Widjaja (V)

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
ORCID: 0000-0002-3190-5633

Sati Alexander (S)

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.

Dahra K Pucher (DK)

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
ORCID: 0000-0002-1935-9289

Christal D Sohl (CD)

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
ORCID: 0000-0002-8048-0205

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Acylation › Acétylation › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Isocitrate dehydrogenases › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Mutagenèse dirigée › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Evaluating Mechanisms of IDH1 Regulation...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Evaluating Mechanisms of IDH1 Regulation...