Sex-Related Differences in Cerebrospinal Fluid Plasma-Derived Proteins of Neurological Patients.
age
albumin quotient
blood-cerebrospinal fluid barrier
cerebrospinal fluid
humans
intrathecal IgG synthesis
sex
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
16 May 2021
16 May 2021
Historique:
received:
06
04
2021
revised:
03
05
2021
accepted:
14
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Cerebrospinal fluid (CSF) protein content presents a sexual dimorphism in humans. We investigated sex-related differences in CSF IgG levels and in the quantification of intrathecal IgG synthesis (IIS). CSF, serum albumin and IgG were measured in 1519 neurological patients and both linear and hyperbolic formulas were used for the quantification of IIS. CSF-restricted oligoclonal IgG bands (OCBs) were used as "gold standard". The linear IgG Index showed a weak agreement with OCBs in males and females (k = 0.559, k = 0.587, respectively), while the hyperbolic Reiber's formulas had a moderate agreement with OCBs in females (k = 0.635) and a weak agreement in males (k = 0.565). Higher CSF albumin and IgG levels were found in men than in women in the whole population and in subjects without IIS after adjusting for age and for serum concentrations of albumin and IgG, respectively (Quade statistics, In neurological patients, men have higher levels of CSF serum-derived proteins, such as albumin and IgG.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Cerebrospinal fluid (CSF) protein content presents a sexual dimorphism in humans. We investigated sex-related differences in CSF IgG levels and in the quantification of intrathecal IgG synthesis (IIS).
METHODS
METHODS
CSF, serum albumin and IgG were measured in 1519 neurological patients and both linear and hyperbolic formulas were used for the quantification of IIS. CSF-restricted oligoclonal IgG bands (OCBs) were used as "gold standard".
RESULTS
RESULTS
The linear IgG Index showed a weak agreement with OCBs in males and females (k = 0.559, k = 0.587, respectively), while the hyperbolic Reiber's formulas had a moderate agreement with OCBs in females (k = 0.635) and a weak agreement in males (k = 0.565). Higher CSF albumin and IgG levels were found in men than in women in the whole population and in subjects without IIS after adjusting for age and for serum concentrations of albumin and IgG, respectively (Quade statistics,
CONCLUSIONS
CONCLUSIONS
In neurological patients, men have higher levels of CSF serum-derived proteins, such as albumin and IgG.
Identifiants
pubmed: 34065720
pii: diagnostics11050884
doi: 10.3390/diagnostics11050884
pmc: PMC8156001
pii:
doi:
Types de publication
Journal Article
Langues
eng
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