Gene Expression Levels of the Prolyl Hydroxylase Domain Proteins
mRNA expression
non-small-cell lung cancer
prognosis
prolyl hydroxylase domain proteins
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 May 2021
12 May 2021
Historique:
received:
29
04
2021
accepted:
06
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Hypoxia correlates with poor prognosis in several cancer types, including lung cancer. Prolyl hydroxylase domain proteins (PHDs) play a role in cell oxygen sensing, negatively regulating the hypoxia-inducible factor (HIF) pathway. Our study aim was to evaluate Tumour tissue samples were obtained from 60 patients with surgically resected NSCLC who were treated with radical surgery. In 22 out of 60 cases, matching morphologically normal lung tissue was obtained. The Our results show that reduced expression of
Sections du résumé
BACKGROUND
BACKGROUND
Hypoxia correlates with poor prognosis in several cancer types, including lung cancer. Prolyl hydroxylase domain proteins (PHDs) play a role in cell oxygen sensing, negatively regulating the hypoxia-inducible factor (HIF) pathway. Our study aim was to evaluate
METHODS
METHODS
Tumour tissue samples were obtained from 60 patients with surgically resected NSCLC who were treated with radical surgery. In 22 out of 60 cases, matching morphologically normal lung tissue was obtained.
RESULTS
RESULTS
The
CONCLUSIONS
CONCLUSIONS
Our results show that reduced expression of
Identifiants
pubmed: 34065840
pii: cancers13102309
doi: 10.3390/cancers13102309
pmc: PMC8150639
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Slovenian Research Agency Grant
ID : J3-7372 and P3-0360
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