Factors Influencing the Adjuvant Therapy Decision: Results of a Real-World Multicenter Data Analysis of 904 Melanoma Patients.

BRAF PD-1 adjuvant treatment checkpoint blocker melanoma targeted therapy

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
12 May 2021
Historique:
received: 05 04 2021
revised: 04 05 2021
accepted: 06 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

Adjuvant treatment of melanoma patients with immune-checkpoint inhibition (ICI) and targeted therapy (TT) significantly improved recurrence-free survival. This study investigates the real-world situation of 904 patients from 13 German skin cancer centers with an indication for adjuvant treatment since the approval of adjuvant ICI and TT. From adjusted log-binomial regression models, we estimated relative risks for associations between various influence factors and treatment decisions (adjuvant therapy yes/no, TT vs. ICI in

Identifiants

pubmed: 34065995
pii: cancers13102319
doi: 10.3390/cancers13102319
pmc: PMC8151445
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : DFG, German Research Foundation
ID : RTG 2535

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Auteurs

Georg Lodde (G)

Department of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.

Andrea Forschner (A)

Department of Dermatology, University Hospital Tuebingen, 72076 Tuebingen, Germany.

Jessica Hassel (J)

Department of Dermatology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Lena M Wulfken (LM)

Skin Cancer Center Hannover, Department of Dermatology and Allergy, Venereology and Allergology, University Hospital Hannover Medical School, 30625 Hannover, Germany.

Friedegund Meier (F)

Skin Cancer Center at the University Cancer Centre Dresden and National Center for Tumor Diseases, 01307 Dresden, Germany.

Peter Mohr (P)

Department of Dermatology, Elbe Kliniken Stade-Buxtehude, 21614 Buxtehude, Germany.

Katharina Kähler (K)

Department of Dermatology, Venereology and Allergology, University Hospital Kiel, 24105 Kiel, Germany.

Bastian Schilling (B)

Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.

Carmen Loquai (C)

Department of Dermatology, University Hospital Mainz, 55131 Mainz, Germany.

Carola Berking (C)

Department of Dermatology, University Hospital Erlangen, CCC-Comprehensive Cancer Center Erlangen-EMN, Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.

Svea Hüning (S)

Department of Dermatology, Klinikum Dortmund gGmbH, 44137 Dortmund, Germany.

Kerstin Schatton (K)

Department of Dermatology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.

Christoffer Gebhardt (C)

Department of Dermatology, Venereology and Allergology, University Hospital Hamburg, 20246 Hamburg, Germany.

Julia Eckardt (J)

Department of Dermatology, University Hospital Tuebingen, 72076 Tuebingen, Germany.

Ralf Gutzmer (R)

Skin Cancer Center Hannover, Department of Dermatology and Allergy, Venereology and Allergology, University Hospital Hannover Medical School, 30625 Hannover, Germany.

Lydia Reinhardt (L)

Skin Cancer Center at the University Cancer Centre Dresden and National Center for Tumor Diseases, 01307 Dresden, Germany.

Valerie Glutsch (V)

Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.

Ulrike Nikfarjam (U)

Department of Dermatology, University Hospital Mainz, 55131 Mainz, Germany.

Michael Erdmann (M)

Department of Dermatology, University Hospital Erlangen, CCC-Comprehensive Cancer Center Erlangen-EMN, Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.

Andreas Stang (A)

Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, 45122 Essen, Germany.

Bernd Kowall (B)

Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, 45122 Essen, Germany.

Alexander Roesch (A)

Department of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.
German Consortium for Translational Cancer Research (DKTK), Partner Site Essen and German Cancer Research Center (DKFZ), 45147 Essen, Germany.

Selma Ugurel (S)

Department of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.

Lisa Zimmer (L)

Department of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.

Dirk Schadendorf (D)

Department of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.
German Consortium for Translational Cancer Research (DKTK), Partner Site Essen and German Cancer Research Center (DKFZ), 45147 Essen, Germany.

Elisabeth Livingstone (E)

Department of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.

Classifications MeSH