Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling.

FAK MEK inhibitor extracellular matrix neurofibromatosis type 1 tumor therapy

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
12 May 2021
Historique:
received: 27 02 2021
revised: 06 05 2021
accepted: 07 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

Plexiform neurofibromas (Pnfs) are benign peripheral nerve sheath tumors that are major features of the human genetic syndrome, neurofibromatosis type 1 (NF1). Pnfs are derived from Schwann cells (SCs) undergoing loss of heterozygosity (LOH) at the

Identifiants

pubmed: 34066061
pii: cancers13102329
doi: 10.3390/cancers13102329
pmc: PMC8150846
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Neurofibromatosis Therapy Acceleration Program
ID : 10 80028823

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Auteurs

Andrea Errico (A)

Department of Surgery, Oncology and Gastroenterology, Veneto Institute of Oncology IOV-IRCCS, University of Padova, 35128 Padova, Italy.

Anna Stocco (A)

Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.

Vincent M Riccardi (VM)

The Neurofibromatosis Institute, La Crescenta, CA 91914, USA.

Alberto Gambalunga (A)

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.

Franco Bassetto (F)

Department of Neurosciences, University of Padova, 35128 Padova, Italy.

Martina Grigatti (M)

Department of Neurosciences, University of Padova, 35128 Padova, Italy.

Amedeo Ferlosio (A)

Department of Biomedicine and Prevention, Anatomic Pathology Institute, Tor Vergata University of Rome, 00133 Rome, Italy.

Gianluca Tadini (G)

Center for Inherited Cutaneous Diseases, University of Milan, 20122 Milan, Italy.

Debora Garozzo (D)

Mediclinic Parkview Hospital, Dubai, United Arab Emirates.

Stefano Ferraresi (S)

Ospedale S. Maria della Misericordia, Divisione di Neurochirurgia, 45100 Rovigo, Italy.

Andrea Trevisan (A)

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.

Sandra Giustini (S)

Department of Clinical, Anesthesiologic and Cardio-Vascular Sciences, University of Sapienza, 00161 Rome, Italy.

Andrea Rasola (A)

Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.

Federica Chiara (F)

Department of Surgery, Oncology and Gastroenterology, Veneto Institute of Oncology IOV-IRCCS, University of Padova, 35128 Padova, Italy.

Classifications MeSH