Pharmacogenetics of the Central Nervous System-Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia.
CNS relapse
CNS toxicity
PRES
childhood leukemia
encephalopathy
genetic polymorphisms
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 May 2021
12 May 2021
Historique:
received:
27
03
2021
revised:
30
04
2021
accepted:
07
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Despite improving cure rates in childhood acute lymphoblastic leukemia (ALL), therapeutic side effects and relapse are ongoing challenges. These can also affect the central nervous system (CNS). Our aim was to identify germline gene polymorphisms that influence the risk of CNS events. Sixty single nucleotide polymorphisms (SNPs) in 20 genes were genotyped in a Hungarian non-matched ALL cohort of 36 cases with chemotherapy related acute toxic encephalopathy (ATE) and 544 controls. Five significant SNPs were further analyzed in an extended Austrian-Czech-NOPHO cohort (
Identifiants
pubmed: 34066083
pii: cancers13102333
doi: 10.3390/cancers13102333
pmc: PMC8151239
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCMG (Czech Republic)
ID : LM2018132
Organisme : St. Anna Kinderkrebsforschung (Austria)
ID : not added
Organisme : New National Excellence Program of the Ministry for Innovation and Technology (Hungary)
ID : UNKP-19-3-IV (JC Sagi)
Organisme : Hungarian Paediatric Oncology Network (Hungary)
ID : 07/MGYH-MGYGYT/2018
Organisme : Swedish Childhood Cancer Fund (Sweden)
ID : KP2017-0010, TJ2020-0082, TJ2019-0031
Organisme : Danish Cancer Society (Denmark)
ID : R150-A10181
Organisme : Danish Childhood Cancer Fund (Denmark)
ID : not added
Organisme : National Research, Development and Innovation Office (NKFIH)
ID : Grants No. PD109200 (ÁF Semsei), PD134449 (A Gézsi) and K115861 (DJ Erdélyi)
Organisme : János Bolyai Research Scholarship of the Hungarian Academy of Sciences (A Gézsi)
ID : not added
Références
Leuk Lymphoma. 2010 Jun;51(6):1063-71
pubmed: 20470218
Biol Blood Marrow Transplant. 2011 Mar;17(3):300-8
pubmed: 20399878
Leuk Res. 2018 Nov;74:10-13
pubmed: 30269037
J Pers Med. 2021 Mar 04;11(3):
pubmed: 33806453
Int J Clin Pharmacol Ther. 2020 May;58(5):254-260
pubmed: 32053102
Curr Res Transl Med. 2021 Jan;69(1):103269
pubmed: 33071214
Leukemia. 2010 Feb;24(2):450-9
pubmed: 20016529
Int J Hematol. 2018 Dec;108(6):630-636
pubmed: 30182170
J Pers Med. 2021 Mar 18;11(3):
pubmed: 33803592
Blood Rev. 2015 Mar;29(2):93-100
pubmed: 25445718
Br J Haematol. 2019 Feb;184(3):405-417
pubmed: 30450575
Pharmacogenomics. 2011 Mar;12(3):379-95
pubmed: 21449677
Blood. 1998 Jul 15;92(2):411-5
pubmed: 9657739
AJNR Am J Neuroradiol. 2019 Feb;40(2):267-275
pubmed: 30679224
Br J Haematol. 2020 Apr;189(2):351-362
pubmed: 31837008
Haematologica. 2021 Feb 11;:
pubmed: 33567813
Pharmacogenetics. 2000 Nov;10(8):715-26
pubmed: 11186134
Pediatr Neurol. 1999 Jul;21(1):476-80
pubmed: 10428434
Lancet Oncol. 2008 Mar;9(3):257-68
pubmed: 18308251
Pharmgenomics Pers Med. 2017 May 12;10:169-181
pubmed: 28546766
Tumour Biol. 2015 Sep;36(10):7599-606
pubmed: 25921280
Pediatr Transplant. 2014 Aug;18(5):518-23
pubmed: 24815062
Pediatr Hematol Oncol. 2010 Feb;27(1):46-52
pubmed: 20121554
Asian Pac J Cancer Prev. 2018 Sep 26;19(9):2535-2543
pubmed: 30256048
Pharmacogenomics J. 2008 Oct;8(5):321-7
pubmed: 17938643
Leukemia. 2017 Feb;31(2):325-332
pubmed: 27451978
Clin Med (Lond). 2016 Oct;16(5):481-485
pubmed: 27697815
Curr Hematol Malig Rep. 2011 Sep;6(3):195-205
pubmed: 21695425
Pharmacogenetics. 2002 Nov;12(8):655-8
pubmed: 12439226
Hematology. 2019 Dec;24(1):369-377
pubmed: 30885098
Hematology. 2017 Jun;22(5):286-291
pubmed: 27960630
Leukemia. 2014 Dec;28(12):2336-43
pubmed: 24781017
Oncotarget. 2017 Jan 3;8(1):110-117
pubmed: 27058755
J Clin Oncol. 2013 Jun 10;31(17):2182-8
pubmed: 23650422
J Clin Oncol. 1999 Dec;17(12):3745-52
pubmed: 10577846
Pediatr Hematol Oncol. 1994 Jul-Aug;11(4):445-9
pubmed: 7947019
Biol Blood Marrow Transplant. 2018 Mar;24(3):501-506
pubmed: 29191665
Indian J Radiol Imaging. 2012 Apr;22(2):98-105
pubmed: 23162250
Ann Hematol. 2020 Nov;99(11):2629-2637
pubmed: 32980890
Expert Opin Pharmacother. 2007 Oct;8(15):2519-31
pubmed: 17931087
Int J Hematol. 2007 Jan;85(1):36-40
pubmed: 17261500
Pediatr Neurol. 2009 Jan;40(1):34-41
pubmed: 19068252
BMC Cancer. 2018 Jul 3;18(1):704
pubmed: 29970035
Haematologica. 2019 Jul;104(7):1396-1406
pubmed: 30630978
Br J Haematol. 2017 Jan;176(2):157-167
pubmed: 27766623
Lancet Oncol. 2016 Jun;17(6):e231-e239
pubmed: 27299279
Pharmacogenomics. 2016 May;17(7):731-41
pubmed: 27180762
N Engl J Med. 2003 Sep 18;349(12):1157-67
pubmed: 13679531
Pediatr Blood Cancer. 2011 Mar;56(3):361-7
pubmed: 21225912
Pharmacogenomics. 2014 Jun;15(8):1105-16
pubmed: 25084203
Pediatr Blood Cancer. 2019 May;66(5):e27594
pubmed: 30592147
Carcinogenesis. 1998 Feb;19(2):275-80
pubmed: 9498276
Rev Environ Health. 2001 Jul-Sep;16(4):263-79
pubmed: 12041882
Nat Med. 2019 Mar;25(3):367-376
pubmed: 30842674
Int J Hematol. 2005 Jan;81(1):39-44
pubmed: 15717687
J Clin Oncol. 2014 Jan 20;32(3):174-84
pubmed: 24344215
Leukemia. 2000 Mar;14(3):369-73
pubmed: 10720128
Blood. 2007 May 15;109(10):4151-7
pubmed: 17264302
Crit Rev Oncol Hematol. 2012 Nov;84(2):274-86
pubmed: 22578745
J Clin Oncol. 1992 Feb;10(2):311-5
pubmed: 1732431
Eur J Paediatr Neurol. 2020 Jul;27:72-77
pubmed: 32340855
Int J Clin Pharm. 2017 Feb;39(1):126-132
pubmed: 27933487
Genet Test Mol Biomarkers. 2016 Oct;20(10):597-602
pubmed: 27533339