Elevated Free Phosphatidylcholine Levels in Cerebrospinal Fluid Distinguish Bacterial from Viral CNS Infections.
biomarker
cell membrane
central nervous system
enterovirus
herpes simplex virus
infection
meningitis
metabolism
varicella zoster virus
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 05 2021
06 05 2021
Historique:
received:
18
03
2021
revised:
21
04
2021
accepted:
23
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
26
10
2021
Statut:
epublish
Résumé
The identification of CSF biomarkers for bacterial meningitis can potentially improve diagnosis and understanding of pathogenesis, and the differentiation from viral CNS infections is of particular clinical importance. Considering that substantial changes in CSF metabolites in CNS infections have recently been demonstrated, we compared concentrations of 188 metabolites in CSF samples from patients with bacterial meningitis (
Identifiants
pubmed: 34066349
pii: cells10051115
doi: 10.3390/cells10051115
pmc: PMC8148106
pii:
doi:
Substances chimiques
Biomarkers
0
Phosphatidylcholines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Helmholtz-Gemeinschaft
ID : iMed
Organisme : Medizinischen Hochschule Hannover
ID : Junge Akademie
Organisme : Helmholtz-Gemeinschaft
ID : Metabolic Dysfunction and Chronic Diseases
Organisme : Deutsche Forschungsgemeinschaft
ID : Cluster of Excellence RESIST (EXC 2155)-Project ID 390874280
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