Development of Exhaustion and Acquisition of Regulatory Function by Infiltrating CD8+CD28- T Lymphocytes Dictate Clinical Outcome in Head and Neck Cancer.

CD8+ T lymphocytes exhaustion head-neck cancer regulatory T cells

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
06 May 2021
Historique:
received: 23 02 2021
revised: 13 04 2021
accepted: 27 04 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

Head and neck squamous cell carcinoma (HNSCC) has a poor clinical outcome despite the presence of a rich CD8+ T cell tumor infiltrate in the majority of patients. This may be due to alterations of tumor infiltrating CD8+ T cells. Here, we performed a characterization of HNSCC infiltrating CD8+ T cells in a cohort of 30 patients. The results showed that differential intratumoral frequency of CD8+CD28+ T cells, CD8+CD28- T cells, and CD8+CD28-CD127-CD39+ Treg distinguished between HNSCC patients who did or did not respond to treatment. Moreover, high PD1 expression identified a CD8+CD28- T cell subpopulation, phenotypically/functionally corresponding to CD8+CD28-CD127-CD39+ Treg, which showed a high expression of markers of exhaustion. This observation suggests that development of exhaustion and acquisition of regulatory properties may configure the late differentiation stage for intratumoral effector T cells, a phenomenon we define as effector-to-regulatory T cell transition.

Identifiants

pubmed: 34066538
pii: cancers13092234
doi: 10.3390/cancers13092234
pmc: PMC8124419
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministero della Salute
ID : Fondi 5x1000 2016

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Auteurs

Daniela Fenoglio (D)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.
Bioterapy Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Liliana Belgioia (L)

Department of Health Science, University of Genoa, 16132 Genoa, Italy.
Radiation Oncology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Alessia Parodi (A)

Bioterapy Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Francesco Missale (F)

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Unit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Almalina Bacigalupo (A)

Department of Health Science, University of Genoa, 16132 Genoa, Italy.
Radiation Oncology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Alison Tarke (A)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Fabiola Incandela (F)

Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, 20133 Milan, Italy.

Simone Negrini (S)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.
Unit of Internal Medicine, Clinical Immunology and Translational Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Stefania Vecchio (S)

Medical Oncology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Tiziana Altosole (T)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Sara Vlah (S)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Giuseppina Astone (G)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Francesca Costabile (F)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Alessandro Ascoli (A)

Unit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy.

Francesca Ferrera (F)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Guido Schenone (G)

Unit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Raffaele De Palma (R)

Unit of Internal Medicine, Clinical Immunology and Translational Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Alessio Signori (A)

Biostatistics Unit, Department of Health Science, University of Genoa, 16132 Genoa, Italy.

Giorgio Peretti (G)

Unit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy.

Renzo Corvò (R)

Department of Health Science, University of Genoa, 16132 Genoa, Italy.
Radiation Oncology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Gilberto Filaci (G)

Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.
Bioterapy Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Classifications MeSH