The Role of AMPK Signaling in Brown Adipose Tissue Activation.
AMPK signaling
brown adipose tissue
energy metabolism
obesity
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 05 2021
06 05 2021
Historique:
received:
29
03
2021
revised:
29
04
2021
accepted:
04
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Obesity is becoming a pandemic, and its prevalence is still increasing. Considering that obesity increases the risk of developing cardiometabolic diseases, research efforts are focusing on new ways to combat obesity. Brown adipose tissue (BAT) has emerged as a possible target to achieve this for its functional role in energy expenditure by means of increasing thermogenesis. An important metabolic sensor and regulator of whole-body energy balance is AMP-activated protein kinase (AMPK), and its role in energy metabolism is evident. This review highlights the mechanisms of BAT activation and investigates how AMPK can be used as a target for BAT activation. We review compounds and other factors that are able to activate AMPK and further discuss the therapeutic use of AMPK in BAT activation. Extensive research shows that AMPK can be activated by a number of different kinases, such as LKB1, CaMKK, but also small molecules, hormones, and metabolic stresses. AMPK is able to activate BAT by inducing adipogenesis, maintaining mitochondrial homeostasis and inducing browning in white adipose tissue. We conclude that, despite encouraging results, many uncertainties should be clarified before AMPK can be posed as a target for anti-obesity treatment via BAT activation.
Identifiants
pubmed: 34066631
pii: cells10051122
doi: 10.3390/cells10051122
pmc: PMC8148517
pii:
doi:
Substances chimiques
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ZonMw
ID : 91715305
Pays : Netherlands
Organisme : ZonMw
ID : 09150161910073
Pays : Netherlands
Organisme : Velux Stiftung
ID : 1063
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