Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature-A New Goal for Early Diagnosis and Therapy?
carcinoma
larynx
miRNA
neuroendocrine
poorly differentiated
squamous
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
08 May 2021
08 May 2021
Historique:
received:
28
03
2021
revised:
27
04
2021
accepted:
29
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous malignancies presenting a wide range of pathological and clinical manifestations. Herein, we retrospectively characterize ten patients diagnosticated with LNEC, five of which were defined as well-moderately differentiated neuroendocrine carcinomas, and five that were defined as poorly differentiated neuroendocrine carcinomas, according to the latest WHO classification. Clinical features were analyzed and compared between the two subgroups together with a microRNA study which evidenced a peculiar signature likely related to poorly differentiated larynx neuroendocrine carcinomas. These findings may offer new useful insights for clinicians to improve diagnosis efficiency, therapy response, and patients' outcome for this aggressive neoplasm.
Identifiants
pubmed: 34066893
pii: jcm10092019
doi: 10.3390/jcm10092019
pmc: PMC8125889
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : POR Campania FESR 2014/2020
ID : project SENSORMIRCIRCOLAR and by FSN 2014-2015-2016 Linea 5/11.
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