Codon Bias Can Determine Sorting of a Potassium Channel Protein.

codon usage dual sorting effect of synonymous codon exchange membrane protein sorting

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
07 05 2021
Historique:
received: 03 03 2021
revised: 30 04 2021
accepted: 05 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 9 11 2021
Statut: epublish

Résumé

Due to the redundancy of the genetic code most amino acids are encoded by multiple synonymous codons. It has been proposed that a biased frequency of synonymous codons can affect the function of proteins by modulating distinct steps in transcription, translation and folding. Here, we use two similar prototype K

Identifiants

pubmed: 34066987
pii: cells10051128
doi: 10.3390/cells10051128
pmc: PMC8151079
pii:
doi:

Substances chimiques

Potassium Channels 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Research Council
ID : 695078
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SPP1926

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Auteurs

Anja J Engel (AJ)

Membrane Biophysics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

Marina Kithil (M)

Membrane Biophysics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

Markus Langhans (M)

Membrane Biophysics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

Oliver Rauh (O)

Membrane Biophysics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

Matea Cartolano (M)

Membrane Biophysics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

James L Van Etten (JL)

Nebraska Center for Virology, Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.

Anna Moroni (A)

Department of Biosciences, University of Milan, 20133 Milan, Italy.

Gerhard Thiel (G)

Membrane Biophysics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

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