The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection.
Antineoplastic Agents
/ pharmacology
Antiviral Agents
/ pharmacology
Arabidopsis
/ metabolism
COVID-19
/ epidemiology
Calcium Channel Blockers
/ pharmacology
Calcium Channels
/ metabolism
Drug Evaluation, Preclinical
Endosomes
/ drug effects
Flavanones
/ pharmacology
Humans
Lysosomes
/ drug effects
Neoplasms
/ blood supply
Neovascularization, Pathologic
/ drug therapy
Pandemics
/ prevention & control
SARS-CoV-2
/ pathogenicity
Vacuoles
/ metabolism
Virus Internalization
/ drug effects
COVID-19 Drug Treatment
SARS-CoV-2
TPC channels
coronavirus
flavonoids
mammalian endolysosome
plant vacuole
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 05 2021
07 05 2021
Historique:
received:
15
04
2021
revised:
01
05
2021
accepted:
04
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
9
6
2021
Statut:
epublish
Résumé
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19.
Identifiants
pubmed: 34067054
pii: cells10051130
doi: 10.3390/cells10051130
pmc: PMC8150892
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Antiviral Agents
0
Calcium Channel Blockers
0
Calcium Channels
0
Flavanones
0
naringenin
HN5425SBF2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Elife. 2019 Mar 12;8:
pubmed: 30860481
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1009-1014
pubmed: 28096396
Biophys J. 1999 Oct;77(4):1973-9
pubmed: 10512817
Biochem Biophys Res Commun. 2005 Jul 1;332(2):465-73
pubmed: 15894288
Cell Calcium. 2010 Jun;47(6):480-90
pubmed: 20621760
Pharmaceuticals (Basel). 2019 Jan 10;12(1):
pubmed: 30634637
Sci Rep. 2017 Mar 02;7:43900
pubmed: 28252105
Biophys J. 1993 Nov;65(5):1837-43
pubmed: 7507716
Phys Chem Chem Phys. 2020 Jul 21;22(27):15664-15674
pubmed: 32618303
Mol Plant. 2011 May;4(3):428-41
pubmed: 21459829
Eur J Pharmacol. 2015 Jan 5;746:96-105
pubmed: 25446569
Microbiol Mol Biol Rev. 2005 Dec;69(4):635-64
pubmed: 16339739
FEBS Lett. 1997 Jul 21;412(1):236-40
pubmed: 9257727
Plant Physiol. 2018 Feb;176(2):1384-1407
pubmed: 29295940
Planta. 2001 Jul;213(3):457-68
pubmed: 11506369
Pharmacol Ther. 2021 Apr;220:107713
pubmed: 33141027
Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4706-15
pubmed: 25331892
J Membr Biol. 1996 Nov;154(1):69-79
pubmed: 8881028
Eur Biophys J. 2003 Mar;32(1):60-6
pubmed: 12632208
Plant Cell. 1994 May;6(5):669-683
pubmed: 12244253
J Membr Biol. 2002 Aug 1;188(3):237-48
pubmed: 12181614
New Phytol. 2017 Dec;216(4):1161-1169
pubmed: 28885692
Diabetes Obes Metab. 2020 Jan;22(1):91-98
pubmed: 31468636
Biochim Biophys Acta. 2016 Mar;1858(3):607-12
pubmed: 26431786
Eur Biophys J. 1999;28(7):552-63
pubmed: 10541793
PLoS One. 2011;6(12):e28923
pubmed: 22205980
J Gen Physiol. 2006 Mar;127(3):329-40
pubmed: 16505151
Nature. 2016 Mar 10;531(7593):196-201
pubmed: 26689363
Autoimmun Rev. 2020 Aug;19(8):102597
pubmed: 32535093
Biophys Chem. 2018 May;236:1-7
pubmed: 29486387
J Chem Inf Model. 2005 Nov-Dec;45(6):1502-6
pubmed: 16309246
New Phytol. 2021 Mar;229(5):3026-3036
pubmed: 33098586
Cell Mol Life Sci. 2018 Oct;75(20):3803-3815
pubmed: 29705952
Sci Rep. 2017 Jul 11;7(1):5121
pubmed: 28698624
Int J Med Sci. 2019 May 7;16(5):644-653
pubmed: 31217731
Trends Pharmacol Sci. 2020 Aug;41(8):582-594
pubmed: 32679067
Biochem J. 2011 Nov 1;439(3):349-74
pubmed: 21992097
Antioxid Redox Signal. 2014 Jul 20;21(3):384-91
pubmed: 24410448
Nature. 2005 Mar 17;434(7031):404-8
pubmed: 15772667
Plant J. 2017 May;90(4):698-707
pubmed: 28112437
Biophys Chem. 2019 Nov;254:106246
pubmed: 31426023
Nat Protoc. 2007;2(7):1565-72
pubmed: 17585298
J Membr Biol. 1999 Jan 15;167(2):127-40
pubmed: 9916144
J Cell Biol. 2009 Jul 27;186(2):201-9
pubmed: 19620632
Curr Opin Physiol. 2020 Oct;17:163-168
pubmed: 32838099
Cell Calcium. 2020 Jun;88:102212
pubmed: 32402856
Nature. 2016 Mar 10;531(7593):258-62
pubmed: 26961658
Plant Physiol. 2015 Oct;169(2):986-95
pubmed: 26282237
Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9095-E9104
pubmed: 30190435
Plant Sci. 2012 Nov;196:67-76
pubmed: 23017900
Cell Mol Life Sci. 2014 Nov;71(21):4275-83
pubmed: 24770793
Sci Rep. 2019 Oct 17;9(1):14906
pubmed: 31624286
Am J Pathol. 1999 Sep;155(3):739-52
pubmed: 10487832
FEBS Lett. 1999 Jan 15;442(2-3):129-32
pubmed: 9928987
EMBO Rep. 2017 Jul;18(7):1100-1107
pubmed: 28536248
PLoS One. 2010 Sep 07;5(9):e12605
pubmed: 20838661
Plant Mol Biol. 2005 Mar;57(4):503-16
pubmed: 15821977
Pharmacol Res. 2018 Sep;135:122-126
pubmed: 30081177
Plant J. 2005 Feb;41(4):606-14
pubmed: 15686523
Nat Chem Biol. 2014 Jun;10(6):463-9
pubmed: 24776928
Science. 2015 Feb 27;347(6225):995-8
pubmed: 25722412
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6497-502
pubmed: 24706854
Sci Rep. 2017 Feb 03;7:41864
pubmed: 28157234
Sci Rep. 2021 Apr 19;11(1):8515
pubmed: 33875769
Plant J. 2011 Nov;68(3):424-32
pubmed: 21736651
FEBS Lett. 2004 Oct 22;576(3):449-54
pubmed: 15498579
Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1678-1686
pubmed: 29746898
Nat Commun. 2019 Jun 14;10(1):2659
pubmed: 31201323
Pharmacol Res. 2021 Jan;163:105255
pubmed: 33096221
J Immunol. 2017 Nov 15;199(10):3466-3477
pubmed: 28993518
J Physiol. 2012 Aug 1;590(15):3421-30
pubmed: 22641774
Plant J. 2009 Apr;58(1):175-82
pubmed: 19067975
J Periodontal Res. 2008 Aug;43(4):400-7
pubmed: 18503517
Nat Commun. 2020 Mar 27;11(1):1620
pubmed: 32221306
Exp Ther Med. 2017 Sep;14(3):2228-2234
pubmed: 28962147
Curr Biol. 2015 Feb 16;25(4):R136-7
pubmed: 25689903
FEBS J. 2018 Jan;285(2):233-243
pubmed: 28656706
Arch Biochem Biophys. 2005 Feb 1;434(1):43-50
pubmed: 15629107
J Exp Bot. 2012 Oct;63(17):6187-97
pubmed: 23105130
Sci Rep. 2019 Nov 8;9(1):16348
pubmed: 31705028
Biochem Biophys Res Commun. 2014 Nov 7;454(1):95-101
pubmed: 25450363
Front Immunol. 2018 Oct 01;9:2267
pubmed: 30327657
Front Microbiol. 2020 Apr 30;11:970
pubmed: 32425923
Plant Physiol. 2016 Jul;171(3):1771-84
pubmed: 27261066
Mol Plant. 2018 Jun 4;11(6):764-775
pubmed: 29614320
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32302401
Front Pharmacol. 2020 Mar 27;11:364
pubmed: 32292344
Eur Biophys J. 2009 Apr;38(4):495-501
pubmed: 19165480
Exp Brain Res. 1999 Jan;124(2):193-9
pubmed: 9928842
J Hepatol. 2011 Nov;55(5):963-71
pubmed: 21354229