From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas.
Animals
Antineoplastic Agents, Alkylating
/ adverse effects
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Biomarkers, Tumor
/ genetics
Brain Neoplasms
/ drug therapy
Cell Line, Tumor
Clinical Trials as Topic
Drug Resistance, Neoplasm
Genetic Predisposition to Disease
Glioma
/ drug therapy
Humans
Isocitrate Dehydrogenase
/ genetics
Mutation
Neoplasm Recurrence, Local
Phenotype
Temozolomide
/ adverse effects
Treatment Outcome
Xenograft Model Antitumor Assays
IDH-mutant glioma
TMZ
combination therapy
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
17 05 2021
17 05 2021
Historique:
received:
09
04
2021
revised:
07
05
2021
accepted:
07
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
27
10
2021
Statut:
epublish
Résumé
In this review, we discuss the use of the alkylating agent temozolomide (TMZ) in the treatment of IDH-mutant gliomas. We describe the challenges associated with TMZ in clinical (drug resistance and tumor recurrence) and preclinical settings (variabilities associated with in vitro models) in treating IDH-mutant glioma. Lastly, we summarize the emerging therapeutic targets that can potentially be used in combination with TMZ.
Identifiants
pubmed: 34067729
pii: cells10051225
doi: 10.3390/cells10051225
pmc: PMC8157002
pii:
doi:
Substances chimiques
Antineoplastic Agents, Alkylating
0
Biomarkers, Tumor
0
Isocitrate Dehydrogenase
EC 1.1.1.41
Temozolomide
YF1K15M17Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Project-ID 404521405, SFB 1389 - UNITE Glioblastoma, Work Package A04
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