Biochemical and Metabolomic Changes after Electromagnetic Hyperthermia Exposure to Treat Colorectal Cancer Liver Implants in Rats.

animal model hyperthermia liver function liver metastases metabolomics

Journal

Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216

Informations de publication

Date de publication:
17 May 2021
Historique:
received: 14 04 2021
revised: 08 05 2021
accepted: 10 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

Hyperthermia (HT) therapy still remains relatively unknown, in terms of both its biological and therapeutic effects. This work aims to analyze the effects of exposure to HT, such as that required in anti-tumor magnetic hyperthermia therapies, using metabolomic and serum parameters routinely analyzed in clinical practice. WAG/RigHsd rats were assigned to the different experimental groups needed to emulate all of the procedures involved in the treatment of liver metastases by HT. Twelve hours or ten days after the electromagnetic HT (606 kHz and 14 kA/m during 21 min), blood samples were retrieved and liver samples were obtained. 1H-nuclear-magnetic-resonance spectroscopy (1H-NMR) was used to search for possible diagnostic biomarkers of HT effects on the rat liver tissue. All of the data obtained from the hydrophilic fraction of the tissues were analyzed and modeled using chemometric tools. Hepatic enzyme levels were significantly increased in animals that underwent hyperthermia after 12 h, but 10 d later they could not be detected anymore. The metabolomic profile (main metabolic differences were found in phosphatidylcholine, taurine, glucose, lactate and pyruvate, among others) also showed that the therapy significantly altered metabolism in the liver within 12 h (with two different patterns); however, those changes reverted to a control-profile pattern after 10 days. Magnetic hyperthermia could be considered as a safe therapy to treat liver metastases, since it does not induce irreversible physiological changes after application.

Sections du résumé

BACKGROUND BACKGROUND
Hyperthermia (HT) therapy still remains relatively unknown, in terms of both its biological and therapeutic effects. This work aims to analyze the effects of exposure to HT, such as that required in anti-tumor magnetic hyperthermia therapies, using metabolomic and serum parameters routinely analyzed in clinical practice.
METHODS METHODS
WAG/RigHsd rats were assigned to the different experimental groups needed to emulate all of the procedures involved in the treatment of liver metastases by HT. Twelve hours or ten days after the electromagnetic HT (606 kHz and 14 kA/m during 21 min), blood samples were retrieved and liver samples were obtained. 1H-nuclear-magnetic-resonance spectroscopy (1H-NMR) was used to search for possible diagnostic biomarkers of HT effects on the rat liver tissue. All of the data obtained from the hydrophilic fraction of the tissues were analyzed and modeled using chemometric tools.
RESULTS RESULTS
Hepatic enzyme levels were significantly increased in animals that underwent hyperthermia after 12 h, but 10 d later they could not be detected anymore. The metabolomic profile (main metabolic differences were found in phosphatidylcholine, taurine, glucose, lactate and pyruvate, among others) also showed that the therapy significantly altered metabolism in the liver within 12 h (with two different patterns); however, those changes reverted to a control-profile pattern after 10 days.
CONCLUSIONS CONCLUSIONS
Magnetic hyperthermia could be considered as a safe therapy to treat liver metastases, since it does not induce irreversible physiological changes after application.

Identifiants

pubmed: 34067780
pii: nano11051318
doi: 10.3390/nano11051318
pmc: PMC8156717
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Agencia Estatal de Investigación (AEI) and European Regional Development Fund (ERDF)
ID : CTM2017-84763-C3-1-R
Organisme : Basque Government
ID : IT-742-13

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Auteurs

Borja Herrero de la Parte (B)

Department of Surgery and Radiology and Physical Medicine, University of The Basque Country, ES48940 Leioa, Biscay, Spain.
Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.

Mireia Irazola (M)

Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.
Department of Analytical Chemistry, University of the Basque Country, ES48940 Leioa, Biscay, Spain.
Research Centre for Experimental Marine Biology & Biotechnology, ES48620 Plentzia, Biscay, Spain.

Jorge Pérez-Muñoz (J)

Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.
Department of Electricity and Electronics, University of The Basque Country, ES48940 Leioa, Biscay, Spain.

Irati Rodrigo (I)

Department of Electricity and Electronics, University of The Basque Country, ES48940 Leioa, Biscay, Spain.

Sira Iturrizaga Correcher (S)

Department of Clinical Analyses, Osakidetza Basque Health Service, Galdakao-Usansolo Hospital, ES48960 Galdakao, Biscay, Spain.

Carmen Mar Medina (C)

Department of Clinical Analyses, Osakidetza Basque Health Service, Galdakao-Usansolo Hospital, ES48960 Galdakao, Biscay, Spain.

Kepa Castro (K)

Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.

Nestor Etxebarria (N)

Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.
Department of Analytical Chemistry, University of the Basque Country, ES48940 Leioa, Biscay, Spain.
Research Centre for Experimental Marine Biology & Biotechnology, ES48620 Plentzia, Biscay, Spain.

Fernando Plazaola (F)

Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.
Department of Electricity and Electronics, University of The Basque Country, ES48940 Leioa, Biscay, Spain.

Jose Ángel García (JÁ)

Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.
Department of Physics, University of the Basque Country, ES48940 Leioa, Biscay, Spain.

Ignacio García-Alonso (I)

Department of Surgery and Radiology and Physical Medicine, University of The Basque Country, ES48940 Leioa, Biscay, Spain.
Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.

Jose Javier Echevarría-Uraga (JJ)

Biocruces Bizkaia Health Research Institute, ES48903 Barakaldo, Biscay, Spain.
Department of Radiology, Osakidetza Basque Health Service, Galdakao-Usansolo Hospital, ES48960 Galdakao, Biscay, Spain.

Classifications MeSH