Influence of Tumor Microenvironment and Fibroblast Population Plasticity on Melanoma Growth, Therapy Resistance and Immunoescape.
Cancer-Associated Fibroblasts
/ metabolism
Cell Communication
Cell Plasticity
/ physiology
Extracellular Matrix
/ metabolism
Fibroblasts
/ physiology
Humans
Melanoma
/ metabolism
Signal Transduction
Skin Neoplasms
/ pathology
Stromal Cells
/ metabolism
Tumor Microenvironment
/ physiology
Melanoma, Cutaneous Malignant
fibroblasts
melanoma
melanoma-associated fibroblasts
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 May 2021
17 May 2021
Historique:
received:
22
04
2021
revised:
13
05
2021
accepted:
14
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Cutaneous melanoma (CM) tissue represents a network constituted by cancer cells and tumor microenvironment (TME). A key feature of CM is the high structural and cellular plasticity of TME, allowing its evolution with disease and adaptation to cancer cell and environmental alterations. In particular, during melanoma development and progression each component of TME by interacting with each other and with cancer cells is subjected to dramatic structural and cellular modifications. These alterations affect extracellular matrix (ECM) remodelling, phenotypic profile of stromal cells, cancer growth and therapeutic response. The stromal fibroblast populations of the TME include normal fibroblasts and melanoma-associated fibroblasts (MAFs) that are highly abundant and flexible cell types interacting with melanoma and stromal cells and differently influencing CM outcomes. The shift from the normal microenvironment to TME and from normal fibroblasts to MAFs deeply sustains CM growth. Hence, in this article we review the features of the normal microenvironment and TME and describe the phenotypic plasticity of normal dermal fibroblasts and MAFs, highlighting their roles in normal skin homeostasis and TME regulation. Moreover, we discuss the influence of MAFs and their secretory profiles on TME remodelling, melanoma progression, targeted therapy resistance and immunosurveillance, highlighting the cellular interactions, the signalling pathways and molecules involved in these processes.
Identifiants
pubmed: 34067929
pii: ijms22105283
doi: 10.3390/ijms22105283
pmc: PMC8157224
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Education, Universities and Research through the grant: "Integrated mechanobiology approaches for a precise medicine in cancer treatment" PRIN-20177TTP3S
ID : PRIN-20177TTP3S
Organisme : Regione Campania "SATIN"
ID : grant 2018-2020
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