B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells.
B cells
autoimmune diseases
autoreactive B cells
tolerance
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 05 2021
13 05 2021
Historique:
received:
15
04
2021
revised:
07
05
2021
accepted:
09
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the production of autoantibodies, secretion of cytokines, and presentation of autoantigens to T cells. However, the mechanisms that underlie the development of autoreactive B cells are not well understood. Here, we review recent studies leveraging novel techniques to identify and characterize (auto)antigen-specific B cells. The insights gained from such studies pertaining to the mechanisms involved in the escape of tolerance checkpoints and the activation of autoreactive B cells are discussed. In addition, we briefly highlight potential therapeutic strategies to target and eliminate autoreactive B cells in autoimmune diseases.
Identifiants
pubmed: 34068035
pii: cells10051190
doi: 10.3390/cells10051190
pmc: PMC8152463
pii:
doi:
Substances chimiques
Immune Checkpoint Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Samenwerkende Gezondheidsfondsen
ID : LSHM18055-SGF
Organisme : Health~Holland
ID : LSHM18055-SGF
Références
Clin Rev Allergy Immunol. 2020 Apr;58(2):213-228
pubmed: 31161341
Mol Immunol. 2000 Feb-Mar;37(3-4):107-13
pubmed: 10865109
Amino Acids. 2005 Jun;28(4):403-8
pubmed: 15895295
J Allergy Clin Immunol. 2010 Nov;126(5):898-907; quiz 908-9
pubmed: 21050940
Arthritis Rheumatol. 2017 Jun;69(6):1313-1324
pubmed: 28141917
J Invest Dermatol. 2008 Dec;128(12):2850-8
pubmed: 18563178
Nat Rev Immunol. 2015 Jul;15(7):441-51
pubmed: 26065586
J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):981-987
pubmed: 30992333
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9727-32
pubmed: 18621685
Arthritis Rheumatol. 2017 Jul;69(7):1440-1450
pubmed: 28296257
J Biol Chem. 1991 May 25;266(15):9540-8
pubmed: 2033050
Blood. 2012 Apr 19;119(16):3744-56
pubmed: 22383797
Immunity. 2014 Oct 16;41(4):529-42
pubmed: 25367570
Crit Rev Immunol. 2018;38(1):17-62
pubmed: 29717662
Am J Clin Dermatol. 2019 Apr;20(2):209-216
pubmed: 30421306
BMC Immunol. 2020 May 18;21(1):27
pubmed: 32423478
Arthritis Rheumatol. 2019 Feb;71(2):196-209
pubmed: 30152202
Immunity. 2008 Aug 15;29(2):249-60
pubmed: 18691914
Arthritis Rheumatol. 2019 Mar;71(3):340-350
pubmed: 30277007
Nat Rev Neurol. 2017 Sep;13(9):533-547
pubmed: 28708133
Cureus. 2019 Oct 6;11(10):e5849
pubmed: 31754584
Clin Rheumatol. 2019 Nov;38(11):2977-2994
pubmed: 31367943
Ann N Y Acad Sci. 2011 Jan;1217:96-121
pubmed: 21251012
Kidney Int. 2021 Jan;99(1):238-246
pubmed: 32592813
Front Immunol. 2013 Jan 17;3:428
pubmed: 23335928
Front Immunol. 2019 Sep 06;10:1990
pubmed: 31555262
J Clin Invest. 2015 Jun;125(6):2194-202
pubmed: 25938780
Arthritis Rheumatol. 2019 Apr;71(4):641-650
pubmed: 30375745
J Clin Invest. 2015 Jun;125(6):2228-33
pubmed: 25893595
Blood Rev. 2020 May;41:100645
pubmed: 31813654
Front Immunol. 2018 Apr 30;9:880
pubmed: 29760702
J Autoimmun. 2017 Nov;84:122-131
pubmed: 28870527
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8039-43
pubmed: 2682636
Curr Top Microbiol Immunol. 2016;393:67-105
pubmed: 26341110
Nat Rev Dis Primers. 2020 Aug 27;6(1):71
pubmed: 32855422
Arthritis Res Ther. 2016 Dec 1;18(1):284
pubmed: 27906052
Arthritis Rheum. 2007 Mar 15;57(2):310-7
pubmed: 17330280
J Autoimmun. 2014 May;50:67-76
pubmed: 24365380
Science. 2016 Jul 8;353(6295):179-84
pubmed: 27365313
Lancet. 2017 May 20;389(10083):2031-2040
pubmed: 28342637
Science. 2003 Sep 5;301(5638):1374-7
pubmed: 12920303
Clin Immunol. 2007 Mar;122(3):330-7
pubmed: 17113829
Curr Opin Immunol. 2006 Jun;18(3):292-7
pubmed: 16616480
Nat Rev Rheumatol. 2018 Mar;14(3):133-145
pubmed: 29416129
Int J Neurosci. 2015 Apr;125(4):235-40
pubmed: 24731000
Blood. 2002 Apr 1;99(7):2562-8
pubmed: 11895794
Nat Rev Dis Primers. 2016 Jun 16;2:16039
pubmed: 27306639
Curr Neuropharmacol. 2017;15(7):938-950
pubmed: 27964705
Rheumatology (Oxford). 2019 Dec 1;58(12):2230-2239
pubmed: 31209475
Cell Res. 2010 Jan;20(1):34-50
pubmed: 20010915
Front Immunol. 2017 Jul 13;8:775
pubmed: 28751890
Nat Rev Dis Primers. 2020 Jul 2;6(1):52
pubmed: 32616746
Nat Rev Immunol. 2017 Jul;17(7):421-436
pubmed: 28393923
J Autoimmun. 2009 Nov-Dec;33(3-4):197-207
pubmed: 19819109
Nat Rev Dis Primers. 2018 Feb 08;4:18001
pubmed: 29417936
Arthritis Res Ther. 2013 Oct 30;15(5):R172
pubmed: 24286296
Front Immunol. 2019 Jul 24;10:1694
pubmed: 31396218
Arthritis Rheum. 2003 Aug;48(8):2146-54
pubmed: 12905467
Immunity. 2003 Dec;19(6):837-47
pubmed: 14670301
N Engl J Med. 2010 Jul 15;363(3):211-20
pubmed: 20647198
Immunity. 2016 Sep 20;45(3):471-482
pubmed: 27653600
N Engl J Med. 2007 Aug 9;357(6):545-52
pubmed: 17687130
Front Immunol. 2019 Aug 07;10:1794
pubmed: 31440235
Int J Biochem Cell Biol. 2008;40(6-7):1317-33
pubmed: 18180196
Arthritis Res Ther. 2013;15 Suppl 1:S3
pubmed: 23566754
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18587-92
pubmed: 20937880
Ann Rheum Dis. 2016 Mar;75(3):578-85
pubmed: 25587188
Nat Rev Dis Primers. 2019 May 2;5(1):30
pubmed: 31048702
Nat Rev Immunol. 2013 Jul;13(7):475-86
pubmed: 23797063
J Exp Med. 2007 Aug 6;204(8):1959-71
pubmed: 17664289
Nature. 2002 Apr 11;416(6881):603-7
pubmed: 11948342
Cell Rep. 2019 Jul 23;28(4):909-922.e6
pubmed: 31340153
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9258-63
pubmed: 15968001
Mol Cell Proteomics. 2017 Feb;16(2):278-287
pubmed: 27956708
Front Immunol. 2020 Nov 26;11:603237
pubmed: 33324420
Front Immunol. 2016 Jun 06;7:198
pubmed: 27375614
Front Immunol. 2016 Feb 08;7:35
pubmed: 26904025
Ann Neurol. 2018 Jan;83(1):13-26
pubmed: 29244240
Immunol Rev. 2009 May;229(1):152-72
pubmed: 19426221
J Clin Invest. 2020 Dec 1;130(12):6317-6324
pubmed: 32817591
Int Immunol. 2005 Jan;17(1):1-14
pubmed: 15585605
Front Immunol. 2019 Jul 02;10:1506
pubmed: 31312206
Cell Mol Immunol. 2013 Mar;10(2):103-6
pubmed: 23241902
J Immunol. 2015 Jan 15;194(2):514-21
pubmed: 25488989
J Exp Med. 1993 Nov 1;178(5):1555-65
pubmed: 7693849
J Immunol. 2016 Feb 15;196(4):1435-41
pubmed: 26851295
Front Immunol. 2019 Jun 14;10:1375
pubmed: 31258541
Clin J Am Soc Nephrol. 2017 Jul 7;12(7):1162-1172
pubmed: 28515156
J Autoimmun. 2004 Feb;22(1):79-85
pubmed: 14709416
Ann Rheum Dis. 2016 Jun;75(6):1170-6
pubmed: 26034045
Eur J Immunol. 2019 Jul;49(7):1107-1116
pubmed: 30893475
Annu Rev Immunol. 2009;27:363-91
pubmed: 19302045
J Exp Med. 2005 Nov 7;202(9):1171-7
pubmed: 16260486
Nat Rev Immunol. 2017 May;17(5):281-294
pubmed: 28368006
Arthritis Rheumatol. 2019 Apr;71(4):529-541
pubmed: 30407753
Annu Rev Immunol. 2018 Apr 26;36:339-357
pubmed: 29356584
Arthritis Rheumatol. 2016 Sep;68(9):2210-20
pubmed: 27059652
Front Immunol. 2020 Feb 18;11:241
pubmed: 32133009
Clin J Am Soc Nephrol. 2016 Jan 7;11(1):137-54
pubmed: 26700440
Ann Rheum Dis. 2021 Feb;80(2):176-184
pubmed: 32998865
Ann Intern Med. 2014 Feb 18;160(4):233-42
pubmed: 24727841
Nat Rev Rheumatol. 2019 May;15(5):303-315
pubmed: 30967621
Arthritis Rheum. 2013 Apr;65(4):1097-106
pubmed: 23334994
Nat Rev Dis Primers. 2017 May 11;3:17026
pubmed: 28492232
Dev Biol. 2010 May 1;341(1):126-40
pubmed: 19854168
N Engl J Med. 2010 Jul 15;363(3):221-32
pubmed: 20647199