Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming.
arthritis
cellular senescence
diet
inflammatory tissue priming
propionate
synovial fibroblasts
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
13 May 2021
13 May 2021
Historique:
received:
30
03
2021
revised:
04
05
2021
accepted:
10
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
23
7
2021
Statut:
epublish
Résumé
Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local application into the joint reduced experimental arthritis and lowered inflammatory tissue priming mediated by synovial fibroblasts. On a cellular level, incubation of synovial fibroblasts with propionate or a physiological mixture of short-chain fatty acids interfered with production of inflammatory mediators and migration and induced immune-regulatory fibroblast senescence. Our study suggests that propionate mediates its alleviating effect on arthritis by direct abrogation of local arthritogenic fibroblast function.
Identifiants
pubmed: 34068191
pii: nu13051643
doi: 10.3390/nu13051643
pmc: PMC8152983
pii:
doi:
Substances chimiques
Propionates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : German Research Foundation (DFG)
ID : DFG - FG 2886 "PANDORA" - projects No. 01 and No.08
Organisme : German Research Foundation (DFG)
ID : CRC1181 - Project no. B07
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