Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease.
Crohn’s disease
inflammatory bowel disease
infliximab
methotrexate
methotrexate polyglutamates
pediatric
ulcerative colitis
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
14 May 2021
14 May 2021
Historique:
received:
28
02
2021
revised:
09
05
2021
accepted:
10
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Inside cells, the immunomodulator methotrexate (MTX) undergoes the addition of glutamates to form methotrexate polyglutamates (MTX-Glu)-promising biomarkers of systemic exposure and treatment response to MTX in rheumatology. MTX-Glu are underexplored in Inflammatory Bowel Disease (IBD), with no data in pediatrics. In this cross-sectional secondary analysis, we assessed the relationships between MTX-Glu and MTX dose and treatment response in pediatric IBD. Twenty-one children with IBD, receiving maintenance therapy with infliximab (IFX) and MTX, had MTX-Glu
Identifiants
pubmed: 34069031
pii: ph14050463
doi: 10.3390/ph14050463
pmc: PMC8156207
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM130423
Pays : United States
Organisme : University of Kansas for Frontiers: University of Kansas Clinical and Translational Science Institute
ID : KL2TR002367
Organisme : NCATS NIH HHS
ID : L40 TR000598
Pays : United States
Organisme : Kansas Institute for Precision Medicine
ID : P20GM130423
Organisme : NCATS NIH HHS
ID : KL2 TR002367
Pays : United States
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