Dermal Delivery of Niacinamide-In Vivo Studies.
confocal Raman spectroscopy
in vitro-in vivo correlation
in vivo
niacinamide
skin permeation
tape stripping
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
14 May 2021
14 May 2021
Historique:
received:
09
04
2021
revised:
30
04
2021
accepted:
10
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
In vivo human studies are considered to be the "gold standard" when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell studies. In the present work, dermal delivery of NIA was investigated in vivo in human subjects using confocal Raman spectroscopy (CRS) and tape stripping (TS). The vehicles investigated included propylene glycol (PG), Transcutol
Identifiants
pubmed: 34069268
pii: pharmaceutics13050726
doi: 10.3390/pharmaceutics13050726
pmc: PMC8156363
pii:
doi:
Types de publication
Journal Article
Langues
eng
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