Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies.
cardiac disease models
cardiomyopathies
drug evaluation
organoids
tissue engineering
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
18 May 2021
18 May 2021
Historique:
received:
15
04
2021
revised:
04
05
2021
accepted:
10
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Cardiac tissue engineering aims at creating contractile structures that can optimally reproduce the features of human cardiac tissue. These constructs are becoming valuable tools to model some of the cardiac functions, to set preclinical platforms for drug testing, or to alternatively be used as therapies for cardiac repair approaches. Most of the recent developments in cardiac tissue engineering have been made possible by important advances regarding the efficient generation of cardiac cells from pluripotent stem cells and the use of novel biomaterials and microfabrication methods. Different combinations of cells, biomaterials, scaffolds, and geometries are however possible, which results in different types of structures with gradual complexities and abilities to mimic the native cardiac tissue. Here, we intend to cover key aspects of tissue engineering applied to cardiology and the consequent development of cardiac organoids. This review presents various facets of the construction of human cardiac 3D constructs, from the choice of the components to their patterning, the final geometry of generated tissues, and the subsequent readouts and applications to model and treat cardiac diseases.
Identifiants
pubmed: 34069816
pii: biomedicines9050563
doi: 10.3390/biomedicines9050563
pmc: PMC8157277
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-17-CE17-0015-02
Organisme : Agence Nationale de la Recherche
ID : ANR-19-CE17-0013-02
Organisme : Fondation pour la Recherche Médicale
ID : EQU201903007852
Organisme : Fondation Leducq
ID : 18CVD05
Organisme : University Research Federation against heart failure
ID : FHU2019, PREVENT_Heart Failure
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