Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients.
Alpha-β-crystallin
colorectal adenocarcinoma
hystological grade
tissues samples
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
18 May 2021
18 May 2021
Historique:
received:
07
05
2021
accepted:
14
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. We comparatively analyzed CRYAB protein expression in 111 CRC tissues and normal adjacent colonic tissue, observing that it was significantly lower in CRC tissues than in corresponding non-cancerous tissues. Moreover, immunohistochemical analysis showed a significant correlation between CRYAB expression and high histological grade G3 (
Identifiants
pubmed: 34069924
pii: diagnostics11050896
doi: 10.3390/diagnostics11050896
pmc: PMC8157605
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : POR FESR REGIONE CAMPANIA
ID : 2014-2020
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