The Mutational Landscape of Acute Myeloid Leukaemia Predicts Responses and Outcomes in Elderly Patients from the PETHEMA-FLUGAZA Phase 3 Clinical Trial.

NGS acute azacytidine clinical trials and observations complete remission cytarabine genetic risk leukemia leukemic cells myelocytic myeloid neoplasia older adults prognostic factors variants

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
18 May 2021
Historique:
received: 14 04 2021
revised: 06 05 2021
accepted: 12 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 6 2021
Statut: epublish

Résumé

We sought to predict treatment responses and outcomes in older patients with newly diagnosed acute myeloid leukemia (AML) from our FLUGAZA phase III clinical trial (PETHEMA group) based on mutational status, comparing azacytidine (AZA) with fludarabine plus low-dose cytarabine (FLUGA). Mutational profiling using a custom 43-gene next-generation sequencing panel revealed differences in profiles between older and younger patients, and several prognostic markers that were useful in young patients were ineffective in older patients. We examined the associations between variables and overall responses at the end of the third cycle. Patients with mutated

Identifiants

pubmed: 34070172
pii: cancers13102458
doi: 10.3390/cancers13102458
pmc: PMC8158477
pii:
doi:

Banques de données

ClinicalTrials.gov
['NCT02319135']

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Instituto de Salud Carlos III
ID : PI16/01530, PI16/01661, PI19/01518 and PI19/00730, CIBERONC; CB16/12/00369
Organisme : CRIS against Cancer foundation
ID : grant 2018/001

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Auteurs

Rosa Ayala (R)

Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain.
Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain.
Departament of Medicine, Complutense University, 28040 Madrid, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.

Inmaculada Rapado (I)

Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain.
Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.

Esther Onecha (E)

Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain.
Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain.

David Martínez-Cuadrón (D)

Hematology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.

Gonzalo Carreño-Tarragona (G)

Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain.
Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain.

Juan Miguel Bergua (JM)

Hematology Department, Hospital San Pedro Acantara, 10003 Cáceres, Spain.

Susana Vives (S)

Department of Hematology, ICO Badalona-Hospital Germans Trias i Pujol. Josep Carreras Leukemia Research Institute. Universitat Autònoma de Barcelona, 08916 Badalona, Spain.

Jesus Lorenzo Algarra (JL)

Hematology Department, Hospital General de Albacete, 02006 Albacete, Spain.

Mar Tormo (M)

Hematology Department, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain.

Pilar Martinez (P)

Hematology Department, Hospital 12 de Octubre, 28041 Madrid, Spain.

Josefina Serrano (J)

Hematology Department, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.

Pilar Herrera (P)

Hematology Department, Hospital Ramon y Cajal, 28034 Madrid, Spain.

Fernando Ramos (F)

Hematology Department, Hospital Universitario de León, 24008 León, Spain.

Olga Salamero (O)

Hematology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.

Esperanza Lavilla (E)

Hematology Department, Hospital Universitario Xeral de Lugo, 27003 Lugo, Spain.

Cristina Gil (C)

Hematology Department, Hospital General de Alicante, 03010 Alicante, Spain.

Jose Luis López Lorenzo (JL)

Hematology Department, Fundación Jiménez Díaz, 28040 Madrid, Spain.

María Belén Vidriales (MB)

Hematology Department, Hospital Universitario de Salamanca, IBSAL, 37007 Salamanca, Spain.

Jorge Labrador (J)

Hematology Department, Hospital Universitario de Burgos, 09001 Burgos, Spain.

José Francisco Falantes (JF)

Hematology Department, Hospital Universitario Vírgen del Rocío, Instituto de BioMedicina de Sevilla, 41013 Sevilla, Spain.

María José Sayas (MJ)

Hematology Department, Hospital Doctor Peset, 46017 Valencia, Spain.

Bruno Paiva (B)

Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.
Hematology Department, Clínica Universitaria de Navarra, 31008 Navarra, Spain.

Eva Barragán (E)

Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.
Hematology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.

Felipe Prosper (F)

Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.
Hematology Department, Clínica Universitaria de Navarra, 31008 Navarra, Spain.

Miguel Ángel Sanz (MÁ)

Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.
Hematology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.

Joaquín Martínez-López (J)

Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain.
Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain.
Departament of Medicine, Complutense University, 28040 Madrid, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.

Pau Montesinos (P)

Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain.
Hematology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.

Classifications MeSH